PMID- 17559577
OWN - NLM
STAT- MEDLINE
DCOM- 20070926
LR  - 20161124
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 70
IP  - 1
DP  - 2007 Jul
TI  - HLA class II amino acid epitopes as susceptibility markers of sarcoidosis.
PG  - 18-27
AB  - Sarcoidosis is a multisystemic disorder of unknown etiology, affecting primarily 
      the lung and characterized by epithelioid granulomas. Disease association studies 
      showed human leukocyte antigen (HLA) class II to be related to sarcoidosis. 
      Initially, we studied the association of sarcoidosis with DQB1, and in the 
      present study, we evaluated all amino acid variants of the HLA-DPB1, -DQB1, 
      -DRB1, -DRB3, -DRB4 and -DRB5 genes to identify possible polymorphisms associated 
      with the disease. Patients and controls were typed for class II genes to the 
      allele level by sequence-based typing. Multiple logistic regression models showed 
      DRAla71 and DQPhe9 to be independently associated with the disease. Subdivision 
      of patients according to their radiographic stage resulted in identification of 
      DRArg74 as independent associated residue in the RS I group, whereas DRAla71 and 
      DQTyr30 were associated with RS II-IV groups. Polymorphic residues specifically 
      associated with sarcoidosis shed new light on the characteristics of 
      sarcoidosis-triggered peptides. Overall, pocket 9 of DQ and pocket 4 of DR seem 
      to be the most important areas involved in the association with sarcoidosis.
FAU - Voorter, C E M
AU  - Voorter CE
AD  - Tissue Typing Laboratory, and Sarcoidosis Management Centre, University Hospital 
      Maastricht, 6202 AZ Maastricht, The Netherlands.
FAU - Amicosante, M
AU  - Amicosante M
FAU - Berretta, F
AU  - Berretta F
FAU - Groeneveld, L
AU  - Groeneveld L
FAU - Drent, M
AU  - Drent M
FAU - van den Berg-Loonen, E M
AU  - van den Berg-Loonen EM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Epitopes)
RN  - 0 (Genetic Markers)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Amino Acid Sequence
MH  - *Epitopes
MH  - Female
MH  - Gene Frequency
MH  - Genetic Markers
MH  - Genetic Predisposition to Disease
MH  - HLA-DR Antigens/chemistry/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Radiography, Thoracic
MH  - Sarcoidosis/blood/classification/diagnostic 
      imaging/*genetics/*immunology/pathology
MH  - Severity of Illness Index
EDAT- 2007/06/15 09:00
MHDA- 2007/09/27 09:00
CRDT- 2007/06/15 09:00
PHST- 2007/06/15 09:00 [pubmed]
PHST- 2007/09/27 09:00 [medline]
PHST- 2007/06/15 09:00 [entrez]
AID - TAN842 [pii]
AID - 10.1111/j.1399-0039.2007.00842.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Jul;70(1):18-27. doi: 10.1111/j.1399-0039.2007.00842.x.