PMID- 17559942
OWN - NLM
STAT- MEDLINE
DCOM- 20080109
LR  - 20221207
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 153
IP  - 1
DP  - 2007 Sep 30
TI  - No association between the tumor necrosis factor-alpha gene promoter 
      polymorphisms and schizophrenia in a Japanese population.
PG  - 1-6
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a pleiotrophic cytokine and exerts 
      neuroprotective and neurodegenerative effects in brain. Several studies have 
      indicated that TNF-alpha is likely related to the pathogenesis of schizophrenia. 
      Recent genetic investigations have revealed that a TNF-alpha gene promoter 
      polymorphism (-G308A) is associated with schizophrenia, although negative 
      findings have also been reported. To assess whether the TNF-alpha gene promoter 
      variants including -G308A could be implicated in vulnerability to schizophrenia, 
      we conducted a case-control association analysis (265 cases and 424 controls) and 
      the transmission disequilibrium test (TDT) analysis (83 trios) for four 
      polymorphisms (-G238A, -G308A, -C857T and -T1031C) in Japanese subjects. In a 
      case-control analysis, there was no significant association between the promoter 
      polymorphisms or haplotypes in the TNF-alpha gene and schizophrenia. In the TDT 
      analysis, we also did not observe transmission distortion. Our results suggest 
      that the above four polymorphisms in the promoter region of the TNF-alpha gene 
      appear not to confer increased susceptibility for schizophrenia in a Japanese 
      population.
FAU - Watanabe, Yuichiro
AU  - Watanabe Y
AD  - Department of Psychiatry, Niigata University Graduate School of Medical and 
      Dental Sciences, Asahimachi-dori 1-757, Niigata 951-8510, Japan.
FAU - Muratake, Tatsuyuki
AU  - Muratake T
FAU - Kaneko, Naoshi
AU  - Kaneko N
FAU - Fukui, Naoki
AU  - Fukui N
FAU - Nara, Yasushi
AU  - Nara Y
FAU - Someya, Toshiyuki
AU  - Someya T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070607
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Asian People/*genetics/psychology
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Predisposition to Disease/genetics
MH  - Haplotypes
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - Promoter Regions, Genetic/*genetics
MH  - Schizophrenia/diagnosis/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2007/06/15 09:00
MHDA- 2008/01/10 09:00
CRDT- 2007/06/15 09:00
PHST- 2005/11/15 00:00 [received]
PHST- 2006/01/31 00:00 [revised]
PHST- 2006/03/01 00:00 [accepted]
PHST- 2007/06/15 09:00 [pubmed]
PHST- 2008/01/10 09:00 [medline]
PHST- 2007/06/15 09:00 [entrez]
AID - S0165-1781(06)00081-3 [pii]
AID - 10.1016/j.psychres.2006.03.009 [doi]
PST - ppublish
SO  - Psychiatry Res. 2007 Sep 30;153(1):1-6. doi: 10.1016/j.psychres.2006.03.009. Epub 
      2007 Jun 7.