PMID- 17559979
OWN - NLM
STAT- MEDLINE
DCOM- 20071218
LR  - 20161018
IS  - 0248-8663 (Print)
IS  - 0248-8663 (Linking)
VI  - 28
IP  - 10
DP  - 2007 Oct
TI  - [Genetic abnormalities in multiple myeloma: role in oncogenesis and impact on 
      survival].
PG  - 677-81
AB  - PURPOSE: Recent development of interphase fluorescence in situ hybridization 
      (FISH) allows analysis on non-proliferant plasma cells. We describe the most 
      frequent genetic abnormalities in multiple myeloma and their prognostic value. 
      CURRENT KNOWLEDGE AND KEY POINTS: Most frequent genetic abnormalities are 
      illegitimate rearrangements involving the IGH gene at 14q32 (60% of patients), 
      hyperdiploidy (50 to 60% of patients), chromosome 13 deletion (40 to -50% of 
      patients), chromosome 1q gain (30 to -40% of patients) chromosome 17 deletion 
      (10% of patients). Some of these genetics abnormalities are observed in 
      monoclonal gammopathy of undetermined significance (MGUS), a pre-malignant state. 
      t(4;14) and t(14;16) translocations and chromosome 17 deletion negatively impact 
      the overall survival. Patients with these genomic aberrations should be treated 
      with specific treatment. FUTURE PROSPECTS AND PROJECTS: Identification of genetic 
      abnormalities is important for evaluation of prognosis and treatment protocol in 
      multiple myeloma.
FAU - Decaux, O
AU  - Decaux O
AD  - Service de medecine interne, hopital Sud, 16 boulevard de Bulgarie, BP 90347, 
      35203 Rennes cedex 02, France. olivier.decaux@chu-rennes.fr
FAU - Lode, L
AU  - Lode L
FAU - Minvielle, S
AU  - Minvielle S
FAU - Avet-Loiseau, H
AU  - Avet-Loiseau H
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Anomalies genetiques dans le myelome: role dans l'oncogenese et implications 
      pronostiques.
DEP - 20070525
PL  - France
TA  - Rev Med Interne
JT  - La Revue de medecine interne
JID - 8101383
SB  - IM
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 1/genetics
MH  - Chromosomes, Human, Pair 13/genetics
MH  - Chromosomes, Human, Pair 14/genetics
MH  - Chromosomes, Human, Pair 17/genetics
MH  - Gene Rearrangement/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Multiple Myeloma/*genetics
MH  - Oncogenes/*genetics
MH  - Prognosis
MH  - Survival Rate
MH  - Translocation, Genetic/genetics
RF  - 29
EDAT- 2007/06/15 09:00
MHDA- 2007/12/19 09:00
CRDT- 2007/06/15 09:00
PHST- 2007/03/19 00:00 [received]
PHST- 2007/04/26 00:00 [accepted]
PHST- 2007/06/15 09:00 [pubmed]
PHST- 2007/12/19 09:00 [medline]
PHST- 2007/06/15 09:00 [entrez]
AID - S0248-8663(07)00554-1 [pii]
AID - 10.1016/j.revmed.2007.04.013 [doi]
PST - ppublish
SO  - Rev Med Interne. 2007 Oct;28(10):677-81. doi: 10.1016/j.revmed.2007.04.013. Epub 
      2007 May 25.