PMID- 17560068
OWN - NLM
STAT- MEDLINE
DCOM- 20080214
LR  - 20151119
IS  - 0753-3322 (Print)
IS  - 0753-3322 (Linking)
VI  - 61
IP  - 10
DP  - 2007 Dec
TI  - Decreased survival in pancreatic cancer patients with high concentrations of 
      organochlorines in adipose tissue.
PG  - 659-64
AB  - We analysed adipose tissue concentrations of persistent organic pollutants (POPs) 
      in 21 cases with exocrine pancreatic cancer. The comparison group consisted of 59 
      subjects. Significantly increased concentrations of polychlorinated biphenyls 
      (PCBs), hexachlorobenzene (HCB), sum of chlordanes and polybrominated 
      diphenylethers (PBDEs) were found in the cases. For 
      1,1,-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE) no significant 
      difference was seen. For PCBs no odds ratio (OR) could be calculated since all 
      cases had concentration>median in controls used as a cut-off. HCB yielded 
      OR=53.0, 95% confidence interval (CI)=4.64-605 and sum of chlordanes OR=18.4, 95% 
      CI=2.71-124 whereas OR was not significantly increased for p,p'-DDE or PBDEs. 
      Body mass index (BMI) at the time of tissue sampling was significantly lower for 
      the cases. This might have influenced the results. Using BMI one year previously 
      or decreasing the concentrations of POPs with the same percentage as weight loss 
      among the cases did not change the results. Survival of the cases was shorter in 
      the group with the concentration of POPs>median among cases, significantly so for 
      the sum of PCBs (147 vs. 294 days), p,p'-DDE (134 vs. 302 days), and sum of 
      chlordanes (142 vs. 294 days) in the high and low group, respectively. The 
      results were based on a low number of cases and should be interpreted with 
      caution.
FAU - Hardell, Lennart
AU  - Hardell L
AD  - Department of Oncology, University Hospital, SE-701 85 Orebro, Sweden. 
      lennart.hardell@orebroll.se
FAU - Carlberg, Michael
AU  - Carlberg M
FAU - Hardell, Karin
AU  - Hardell K
FAU - Bjornfoth, Helen
AU  - Bjornfoth H
FAU - Wickbom, Gunnar
AU  - Wickbom G
FAU - Ionescu, Mircea
AU  - Ionescu M
FAU - van Bavel, Bert
AU  - van Bavel B
FAU - Lindstrom, Gunilla
AU  - Lindstrom G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070522
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Hydrocarbons, Brominated)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticide Residues)
RN  - 12789-03-6 (Chlordan)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adipose Tissue/chemistry/*metabolism
MH  - Aged
MH  - Aged, 80 and over
MH  - Chlordan/analysis
MH  - Confidence Intervals
MH  - Dichlorodiphenyl Dichloroethylene/analysis
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Brominated/analysis/metabolism
MH  - Hydrocarbons, Chlorinated/analysis/*metabolism
MH  - Life Style
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Pancreatic Neoplasms/*metabolism/*mortality
MH  - Pesticide Residues/analysis
MH  - Polychlorinated Biphenyls/analysis
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Survival
MH  - Survival Analysis
MH  - Sweden/epidemiology
EDAT- 2007/06/15 09:00
MHDA- 2008/02/15 09:00
CRDT- 2007/06/15 09:00
PHST- 2007/04/09 00:00 [received]
PHST- 2007/04/20 00:00 [accepted]
PHST- 2007/06/15 09:00 [pubmed]
PHST- 2008/02/15 09:00 [medline]
PHST- 2007/06/15 09:00 [entrez]
AID - S0753-3322(07)00082-0 [pii]
AID - 10.1016/j.biopha.2007.04.006 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2007 Dec;61(10):659-64. doi: 10.1016/j.biopha.2007.04.006. 
      Epub 2007 May 22.