PMID- 17560556
OWN - NLM
STAT- MEDLINE
DCOM- 20071026
LR  - 20220321
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 62
IP  - 5
DP  - 2007 Sep 1
TI  - Correlation between serum brain-derived neurotrophic factor level and an in vivo 
      marker of cortical integrity.
PG  - 530-5
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) signaling at synapses 
      improves synaptic strengthening associated with learning and memory. In the 
      present study we hypothesized that serum BDNF concentration is associated with in 
      vivo level of cerebral N-acetylaspartate (NAA), a well established marker of 
      neuronal integrity. METHODS: In 36 healthy subjects BDNF serum concentration and 
      absolute concentration of NAA together with other metabolites were measured by 
      proton magnetic resonance spectroscopy (1H-MRS) in regions with high BDNF levels 
      (anterior cingulate cortex [ACC], left hippocampus). Relationship between BDNF 
      concentration and brain metabolites was studied in linear regression analysis 
      with BDNF concentration as dependent variable and metabolite concentrations, age, 
      and gender as predictor variables. RESULTS: The BDNF serum concentrations were 
      positively associated with the concentrations of NAA (T = 2.193, p = .037) and 
      total choline (T = 1.997, p = .055; trend) but not total creatine or glutamate in 
      the ACC. No significant association was observed between BDNF serum concentration 
      and absolute metabolite concentrations in the hippocampus. CONCLUSIONS: The 
      preliminary data might indicate that BDNF serum concentration reflects some 
      aspects of neuronal plasticity as indicated by its association with NAA level in 
      the cerebral cortex. The results would be in line with the notion that BDNF plays 
      a central role in the regulation of neuronal survival and differentiation in the 
      human brain.
FAU - Lang, Undine E
AU  - Lang UE
AD  - Department of Psychiatry and Psychotherapy, Charite-University Medicine Berlin, 
      Campus Mitte, Berlin, Germany.
FAU - Hellweg, Rainer
AU  - Hellweg R
FAU - Seifert, Frank
AU  - Seifert F
FAU - Schubert, Florian
AU  - Schubert F
FAU - Gallinat, Juergen
AU  - Gallinat J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070608
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Protons)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 997-55-7 (N-acetylaspartate)
RN  - MU72812GK0 (Creatine)
RN  - N91BDP6H0X (Choline)
SB  - IM
MH  - Adult
MH  - Aspartic Acid/analogs & derivatives/analysis
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cerebral Cortex/chemistry/*physiology
MH  - Choline/analysis
MH  - Creatine/analysis
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - Middle Aged
MH  - Protons
EDAT- 2007/06/15 09:00
MHDA- 2007/10/30 09:00
CRDT- 2007/06/15 09:00
PHST- 2006/10/12 00:00 [received]
PHST- 2007/01/03 00:00 [revised]
PHST- 2007/01/03 00:00 [accepted]
PHST- 2007/06/15 09:00 [pubmed]
PHST- 2007/10/30 09:00 [medline]
PHST- 2007/06/15 09:00 [entrez]
AID - S0006-3223(07)00009-1 [pii]
AID - 10.1016/j.biopsych.2007.01.002 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2007 Sep 1;62(5):530-5. doi: 10.1016/j.biopsych.2007.01.002. 
      Epub 2007 Jun 8.