PMID- 17562353
OWN - NLM
STAT- MEDLINE
DCOM- 20070914
LR  - 20081121
IS  - 0300-9084 (Print)
IS  - 0300-9084 (Linking)
VI  - 89
IP  - 6-7
DP  - 2007 Jun-Jul
TI  - Dendritic cells and interferon-mediated autoimmunity.
PG  - 856-71
AB  - Dendritic cells (DCs) are central cells of the immune responses. They can be 
      considered as the most influential antigen-presenting cells in the body because 
      of their unique role in initiating immunity against most types of antigens. 
      Recent studies have clearly established that the state of maturation of DC can be 
      crucial for the ability of these antigen-presenting cells to inhibit or induce 
      T-cell-mediated autoimmune diseases. Type I interferon has been shown to be 
      produced at very high amounts by a specific type of DC (pDC). In recent years, 
      the study of multiple autoimmune diseases has pointed to a central role for type 
      I interferon (IFN-I) in disease pathogenesis, in particular through the 
      IFN-molecular signature deciphered in some of these diseases. One hypothesis 
      would be that IFN directly affects multiple actors of the immune reaction such as 
      T cells and B cells and that it can induce the unabated activation of peripheral 
      dendritic cells. On the other hand, type II IFN has been considered as pathogenic 
      in multiple autoimmune diseases leading to the paradigm of TH-1 type autoimmune 
      diseases. The discovery of the TH-17 type of cells and the protective role 
      IFN-gamma can exert on particular phases of these diseases urge one to 
      re-evaluate this assumption.
FAU - Gottenberg, Jacques-Eric
AU  - Gottenberg JE
AD  - Departement d'Immunologie, Institut Cochin, Universite Paris Descartes, CNRS (UMR 
      8104), Paris, France.
FAU - Chiocchia, Gilles
AU  - Chiocchia G
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20070505
PL  - France
TA  - Biochimie
JT  - Biochimie
JID - 1264604
RN  - 0 (Receptors, Interferon)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Animals
MH  - Arthritis, Rheumatoid/metabolism
MH  - Autoimmune Diseases/metabolism
MH  - *Autoimmunity
MH  - Dendritic Cells/*cytology
MH  - Diabetes Mellitus, Type 1/metabolism
MH  - Disease Models, Animal
MH  - Humans
MH  - Inflammation
MH  - Interferon-gamma/metabolism
MH  - Interferons/*metabolism
MH  - Lupus Erythematosus, Systemic/metabolism
MH  - Models, Biological
MH  - Multiple Sclerosis/metabolism
MH  - Receptors, Interferon/metabolism
RF  - 197
EDAT- 2007/06/15 09:00
MHDA- 2007/09/15 09:00
CRDT- 2007/06/15 09:00
PHST- 2007/02/22 00:00 [received]
PHST- 2007/04/23 00:00 [accepted]
PHST- 2007/06/15 09:00 [pubmed]
PHST- 2007/09/15 09:00 [medline]
PHST- 2007/06/15 09:00 [entrez]
AID - S0300-9084(07)00108-3 [pii]
AID - 10.1016/j.biochi.2007.04.013 [doi]
PST - ppublish
SO  - Biochimie. 2007 Jun-Jul;89(6-7):856-71. doi: 10.1016/j.biochi.2007.04.013. Epub 
      2007 May 5.