PMID- 17563258
OWN - NLM
STAT- MEDLINE
DCOM- 20070625
LR  - 20190917
IS  - 1744-7666 (Electronic)
IS  - 1465-6566 (Linking)
VI  - 8
IP  - 9
DP  - 2007 Jun
TI  - Latest medical treatment strategies for venous thromboembolism.
PG  - 1221-33
AB  - Anticoagulant therapy with unfractionated heparin (UFH) followed by warfarin 
      prevents thrombus extension, reduces the risk of recurrent thrombosis and 
      prevents death in patients with venous thromboembolism (VTE). 
      Low-molecular-weight heparin (LMWH) has replaced UFH as the preferred initial 
      anticoagulant therapy for VTE because it is as effective and safe as UFH, but 
      does not require laboratory monitoring and is less likely to cause immune 
      thrombocytopenia and osteoporosis. More recently, fondaparinux has been shown to 
      be an effective and safe alternative to LMWH and several new parenteral 
      anticoagulants are being evaluated. The most important unmet need in the 
      anticoagulant management of VTE is a replacement for warfarin. New oral 
      anticoagulants that selectively target individual steps in the coagulation 
      cascade have been shown to be effective for the long-term treatment of VTE in 
      Phase II and III trials and are likely to become available in the near future.
FAU - McRae, Simon J
AU  - McRae SJ
AD  - The Queen Elizabeth Hospital, Institute of Medical and Veterinary Sciences, 
      Department of Haematology-Oncology, 28 Woodville Rd, Woodville 5011, Adelaide, 
      South Australia, Australia. Simon.Mcrae@imvssa.gov.au
FAU - Eikelboom, John W
AU  - Eikelboom JW
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Expert Opin Pharmacother
JT  - Expert opinion on pharmacotherapy
JID - 100897346
RN  - 0 (Anticoagulants)
SB  - IM
MH  - Anticoagulants/therapeutic use
MH  - Blood Coagulation
MH  - Humans
MH  - Thromboembolism/*drug therapy/physiopathology
MH  - Venous Thrombosis/*drug therapy/physiopathology
RF  - 94
EDAT- 2007/06/15 09:00
MHDA- 2007/06/26 09:00
CRDT- 2007/06/15 09:00
PHST- 2007/06/15 09:00 [pubmed]
PHST- 2007/06/26 09:00 [medline]
PHST- 2007/06/15 09:00 [entrez]
AID - 10.1517/14656566.8.9.1221 [doi]
PST - ppublish
SO  - Expert Opin Pharmacother. 2007 Jun;8(9):1221-33. doi: 10.1517/14656566.8.9.1221.