PMID- 17563408
OWN - NLM
STAT- MEDLINE
DCOM- 20080904
LR  - 20181201
IS  - 1735-1502 (Print)
IS  - 1735-1502 (Linking)
VI  - 6
IP  - 2
DP  - 2007 Jun
TI  - The opposite associations of lycopene and body fat mass with humoral immunity in 
      type 2 diabetes mellitus: a possible role in atherogenesis.
PG  - 79-87
AB  - This study examined the possible effects of lycopene at physiological dosage and 
      body fat mass on the humoral immune response in patients with type 2 diabetes 
      mellitus (T2DM). A total of 35 patients with Typ2 diabetes mellitus from both 
      sexes aged 54+/-9 yrs from the Iranian Diabetes Society were introduced into a 
      double blind placebo controlled clinical trial conducted for 2 months. After a 
      2-week lycopene free diet washout period, patients were allocated to either 
      lycopene supplementation group (10mg/d) (n=16) or placebo age- and sex matched 
      group (n=19) for 8 weeks. Patients were instructed to keep their diets and 
      physical activities as unchanged as possible. Lycopene supplements increased 
      serum lycopene levels (p<0.001). While intake of dietary energy and nutrients did 
      not change in either groups, the ratio of total antioxidant capacity to 
      malondialdehyde increased significantly in the lycopene group (p=0.007). There 
      was an inverse correlation between serum levels of lycopene and those of IgG (r= 
      -0.338, p=0.008). On the contrary, changes of serum levels of lycopene directly 
      correlated with those of IgM (r=0.466, p=0.005). Interestingly, changes of the 
      amount of fat mass correlated directly with those of serum IgG (r=0.415, p=0.044) 
      but inversely with of serum IgM (r= -0.469, p=0.021). While truncal fat might 
      promote adaptive humoral immunity, lycopene probably by inhibiting MDA-LDL 
      formation might attenuate T cell dependent adaptive (pro-atherogenic) humoral 
      immune response. These findings may have preventive implications in long term 
      diabetic complications, notably atherogenesis.
FAU - Neyestani, Tirang R
AU  - Neyestani TR
AD  - Laboratory of Nutrition Research, National Nutrition and Food Technology Research 
      Institute, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. 
      tneyestani@nnftri.ac.ir
FAU - Shariat-Zadeh, Nastaran
AU  - Shariat-Zadeh N
FAU - Gharavi, A'azam
AU  - Gharavi A
FAU - Kalayi, Ali
AU  - Kalayi A
FAU - Khalaji, Niloufar
AU  - Khalaji N
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
RN  - 0 (Antioxidants)
RN  - 0 (Immunoglobulins)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (oxidized low density lipoprotein)
RN  - 01YAE03M7J (beta Carotene)
RN  - 36-88-4 (Carotenoids)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - SB0N2N0WV6 (Lycopene)
SB  - IM
MH  - *Adipose Tissue/growth & development/immunology/metabolism
MH  - *Antibody Formation
MH  - Antioxidants/administration & dosage/metabolism
MH  - Atherosclerosis/etiology/prevention & control
MH  - *Carotenoids/administration & dosage/blood/deficiency
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/complications/*diet therapy/*immunology/physiopathology
MH  - Female
MH  - Humans
MH  - Immunoglobulins/blood
MH  - Lipoproteins, LDL/blood
MH  - Lycopene
MH  - Male
MH  - Malondialdehyde/blood
MH  - Middle Aged
MH  - Oxidation-Reduction
MH  - Oxidative Stress
MH  - beta Carotene/blood
EDAT- 2007/06/15 09:00
MHDA- 2008/09/05 09:00
CRDT- 2007/06/15 09:00
PHST- 2007/06/15 09:00 [pubmed]
PHST- 2008/09/05 09:00 [medline]
PHST- 2007/06/15 09:00 [entrez]
AID - 06027987 [pii]
PST - ppublish
SO  - Iran J Allergy Asthma Immunol. 2007 Jun;6(2):79-87.