PMID- 17563734
OWN - NLM
STAT- MEDLINE
DCOM- 20071227
LR  - 20220321
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 40
IP  - 3
DP  - 2007 Aug
TI  - Lower costs associated with hematopoietic cell transplantation using reduced 
      intensity vs high-dose regimens for hematological malignancy.
PG  - 209-17
AB  - We compared inpatient and outpatient costs alongside clinical outcomes associated 
      with hematopoietic cell transplantation between 2000 and 2003 with high-dose 
      regimens (HDCT, n=185) and with reduced intensity regimens (RICT, n=90) from 
      human leukocyte antigen (HLA)-matched donors for patients with hematological 
      malignancies. With a comparable median follow-up of 3 years, long-term clinical 
      outcomes, including cumulative incidence of chronic graft-vs-host disease, 
      disease-free survival and overall survival, were similar between the two groups. 
      In the univariate analysis, median costs for the first 100 days ($104,380 vs 
      $42,149) and 1 year ($128,253 vs $80,499) in the HDCT group were higher than 
      those in the RICT group. Median days of hospitalization are also higher for HDCT 
      recipients (39 vs 21), although the number of outpatient clinic visits for HDCT 
      recipients were fewer compared to that for RICT recipients (16 vs 25) during the 
      first year. Adjusting for patient characteristics, RICT recipients had 
      approximately 16 fewer days of hospitalization and cost $53,030 less than HDCT 
      recipients within the first year after transplantation. Our data suggest that 
      substantially lower costs and fewer days of hospitalization within the first year 
      after RICT procedures can be obtained with no compromise of long-term clinical 
      outcomes compared to HDCT procedures.
FAU - Saito, A M
AU  - Saito AM
AD  - Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, 
      USA. akiko_saito@dfci.harvard.edu
FAU - Zahrieh, D
AU  - Zahrieh D
FAU - Cutler, C
AU  - Cutler C
FAU - Ho, V T
AU  - Ho VT
FAU - Antin, J H
AU  - Antin JH
FAU - Soiffer, R J
AU  - Soiffer RJ
FAU - Alyea, E P
AU  - Alyea EP
FAU - Lee, S J
AU  - Lee SJ
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
DEP - 20070611
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Ambulatory Care/*economics
MH  - Child
MH  - Costs and Cost Analysis
MH  - Disease-Free Survival
MH  - Female
MH  - Follow-Up Studies
MH  - Graft vs Host Disease/economics/mortality
MH  - Hematologic Neoplasms/*economics/mortality/therapy
MH  - Hematopoietic Stem Cell Transplantation/*economics/mortality
MH  - Humans
MH  - Incidence
MH  - Length of Stay/*economics
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Survival Rate
EDAT- 2007/06/15 09:00
MHDA- 2007/12/28 09:00
CRDT- 2007/06/15 09:00
PHST- 2007/06/15 09:00 [pubmed]
PHST- 2007/12/28 09:00 [medline]
PHST- 2007/06/15 09:00 [entrez]
AID - 1705733 [pii]
AID - 10.1038/sj.bmt.1705733 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2007 Aug;40(3):209-17. doi: 10.1038/sj.bmt.1705733. Epub 
      2007 Jun 11.