PMID- 17565327
OWN - NLM
STAT- MEDLINE
DCOM- 20070731
LR  - 20071203
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 83
IP  - 11
DP  - 2007 Jun 15
TI  - Acute allograft rejection occurs independently of inducible heat shock 
      protein-70.
PG  - 1513-7
AB  - Dendritic cells (DCs) are key mediators of the innate response to 
      transplantation. Yet, the substances that activate these cells during acute 
      allograft rejection remain elusive. Previous work has suggested that heat shock 
      protein (HSP)-70 is associated with acute allograft rejection. Hence, the goal of 
      this study was to determine whether HSP-70 activates DCs and plays a critical 
      role in acute allograft rejection in an experimental model that is dependent on 
      innate MyD88 signaling. Our in vitro data indicate that HSP-70 does not activate 
      DCs. In vivo transplant studies demonstrate that HSP-70 levels are not increased 
      during acute allograft rejection and that an absence of the inducible form of 
      HSP-70 neither delays acute allograft rejection, impairs DCs maturation, nor 
      alters Th1 immune responses during acute allograft rejection. In conclusion, our 
      results indicate that HSP-70 in our experimental models does not play an 
      essential role in acute allograft rejection.
FAU - Tesar, Bethany M
AU  - Tesar BM
AD  - Department of Internal Medicine, Yale University School of Medicine, New Haven, 
      CT 06520, USA.
FAU - Goldstein, Daniel R
AU  - Goldstein DR
LA  - eng
GR  - AI064660/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Bone Marrow Cells/drug effects/immunology
MH  - Cells, Cultured
MH  - Dendritic Cells/drug effects/immunology
MH  - Graft Rejection/*etiology/metabolism/*physiopathology
MH  - HSP70 Heat-Shock Proteins/*metabolism/pharmacology
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Mice, Knockout
MH  - Recombinant Proteins/pharmacology
MH  - *Skin Transplantation
MH  - Transplantation, Homologous
EDAT- 2007/06/15 09:00
MHDA- 2007/08/01 09:00
CRDT- 2007/06/15 09:00
PHST- 2007/06/15 09:00 [pubmed]
PHST- 2007/08/01 09:00 [medline]
PHST- 2007/06/15 09:00 [entrez]
AID - 00007890-200706150-00016 [pii]
AID - 10.1097/01.tp.0000263345.86078.10 [doi]
PST - ppublish
SO  - Transplantation. 2007 Jun 15;83(11):1513-7. doi: 
      10.1097/01.tp.0000263345.86078.10.