PMID- 17565416
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20200622
IS  - 1614-0575 (Electronic)
IS  - 1613-6071 (Print)
IS  - 1613-6071 (Linking)
VI  - 4
IP  - 1
DP  - 2007 Spring
TI  - Association of Resistin Gene 3'-Untranslated Region EX4-44G-->A Polymorphism with 
      Obesity- and Insulin-Related Phenotypes in Turkish Type 2 Diabetes Patients.
PG  - 49-55
AB  - Resistin, an adipocyte-secreted hormone, has been associated with obesity, 
      insulin resistance and type 2 diabetes mellitus (T2DM) in some, but not all, 
      rodent models. In humans, the exact function of resistin is unkown. Because 
      3'-untranslated region (3'-UTR) single nucleotide substitutions (SNPs) have been 
      shown to affect gene expression, we examined the EX4-44G-->A SNP in the 3'-UTR of 
      exon 3 within the resistin gene. The objective of this study was to investigate, 
      for the first time in a Turkish study group, whether the 3'-UTR EX4-44G-->A 
      variation in the resistin gene influences the development of T2DM, obesity and 
      insulin-related phenotypes. We analyzed the genotype frequencies of the 
      EX4-44G-->A polymorphism of the resistin gene in 116 type 2 diabetic and 102 
      normal subjects. Serum lipids, obesity-related and insulin-related phenotypes 
      were analyzed. No significant difference for genotypic frequencies were observed 
      for the BseRI restriction site in type 2 diabetic patients as compared to 
      controls. Waist-to-hip ratio, BMI, body fat and apoAI levels were found to be 
      affected by resistin genotype. In the control group, BMI (p < 0.01), HIS (p < 
      0.05) and BF (p < 0.05) levels were found to be elevated, whereas HOMA beta-cell 
      index (p < 0.01) and apo AI (p < 0.05) levels were found to be decreased in GG 
      genotype carriers. In the diabetic group, the GG genotype carriers were found to 
      have higher BMI levels (p < 0.001), waist-to-hip ratio (p < 0.05), body fat (p < 
      0.01), HOMA (p < 0.001) and fasting insulin (p < 0.05), but lower HbA1c levels in 
      comparison to GC + AA carriers. These data suggest that, in the Turkish study 
      group, the EX4-44G-->A polymorphism of the resistin gene is associated with 
      insulin and obesity-related phenotypes.
FAU - Duman, Belgin Susleyici
AU  - Duman BS
AD  - Department of Medical Biology and Genetics, Faculty of Medicine, Istanbul Science 
      University, Istanbul, Turkey.
FAU - Cagatay, Penbe
AU  - Cagatay P
FAU - Hatemi, Husrev
AU  - Hatemi H
FAU - Ozturk, Melek
AU  - Ozturk M
LA  - eng
PT  - Journal Article
DEP - 20070510
PL  - Singapore
TA  - Rev Diabet Stud
JT  - The review of diabetic studies : RDS
JID - 101227575
PMC - PMC1892521
EDAT- 2007/06/15 09:00
MHDA- 2007/06/15 09:01
PMCR- 2008/05/10
CRDT- 2007/06/15 09:00
PHST- 2007/06/15 09:00 [pubmed]
PHST- 2007/06/15 09:01 [medline]
PHST- 2007/06/15 09:00 [entrez]
PHST- 2008/05/10 00:00 [pmc-release]
AID - 10.1900/RDS.2007.4.49 [doi]
PST - ppublish
SO  - Rev Diabet Stud. 2007 Spring;4(1):49-55. doi: 10.1900/RDS.2007.4.49. Epub 2007 
      May 10.