PMID- 17565837
OWN - NLM
STAT- MEDLINE
DCOM- 20081021
LR  - 20131121
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 87
IP  - 11
DP  - 2007 Mar 20
TI  - [Association of monocyte chemoattractant protein-1 and the clinical 
      characteristics of polycystic ovary syndrome: analysis of 65 cases].
PG  - 721-4
AB  - OBJECTIVE: To investigate the association of monocyte chemoattractant protein-1 
      (MCP-1) and the clinical characteristics of polycystic ovary syndrome: (PCOS). 
      METHODS: Fasting peripheral venous blood samples were collected on the 2nd or 3rd 
      day of the menstrual cycle or when there was no dominant follicle shown by 
      ultrasonography after amenorrhea from 65 POCS patients, aged 30 +/- 3, 27 being 
      attributed to the obese group according the body mass index (BMI) and 38 to the 
      non-obese group, and 40 patients with infertility, aged 31 +/- 3, as controls, 
      subdivided into obese and non-obese subgroups (both n = 20), and then the samples 
      of serum. Were obtained. The level of MCP-1 was examined by ELISA. The levels of 
      prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), 
      estradiol, and testosterone (T) were assayed with chemoluminescence methods, and 
      the level of androstenedione was detected by radioimmunoassay. The level of serum 
      insulin was detected by chemoluminescence method and the serum glucose (SG) was 
      detected by oxidase enzymic method. Insulin sensitivity index (ISI) and 
      homeostasis model assessment insulin resistance (HOMA-IR) were calculated. 
      RESULTS: (1) The levels of serum LH, T, and LH/FSH of the obese and non-obese 
      POCS subgroups were all significantly higher than the corresponding obese and 
      non-obese control subgroups (all P < 0.05). (2) The level of MCP-1 of the 
      non-obese PCOS subgroup was (98 +/- 67) ng/ml, significantly higher than that of 
      the non-obese controls [(58 +/- 41 mg/L, P < 0.05)]. (3) Pearson correlation 
      showed that serum PCP-1 was significantly positively correlated with BMI (r = 
      0.339, P = 0.000). LH (r = 0.224, P = 0.024)), and HOMA-IR (r = 0.239, P = 
      0.016), and significantly negatively correlated with ISI (r = -0.250, P = 
      0.0006). (3) Multiple regression analysis showed that BMI and LH were the 
      principal factors influencing the level of MCP-1 in the POCS patients. 
      CONCLUSION: The serum level of MCP-1 is associated with the LH level in POCS 
      patients. POCS may a chronic inflammatory disease. MCP-1 is likely to participate 
      in obesity, hyperinsulinemia, and insulin resistance in POCS.
FAU - Hu, Wei-Hong
AU  - Hu WH
AD  - Department of Obstetrics and Gynecology, Peking University Third Hospital, 
      Beijing 100083, China.
FAU - Qiao, Jie
AU  - Qiao J
FAU - Li, Mei-Zhi
AU  - Li MZ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Chemokine CCL2)
RN  - 0 (Follicle Stimulating Hormone, Human)
RN  - 3XMK78S47O (Testosterone)
RN  - 9002-67-9 (Luteinizing Hormone)
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Follicle Stimulating Hormone, Human/blood
MH  - Humans
MH  - Hyperinsulinism/blood/etiology
MH  - Insulin Resistance
MH  - Luteinizing Hormone/blood
MH  - Obesity/blood/etiology
MH  - Polycystic Ovary Syndrome/*blood/complications/*pathology
MH  - Testosterone/blood
EDAT- 2007/06/15 09:00
MHDA- 2008/10/22 09:00
CRDT- 2007/06/15 09:00
PHST- 2007/06/15 09:00 [pubmed]
PHST- 2008/10/22 09:00 [medline]
PHST- 2007/06/15 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2007 Mar 20;87(11):721-4.