PMID- 17566520
OWN - NLM
STAT- MEDLINE
DCOM- 20070907
LR  - 20070614
IS  - 0009-9074 (Print)
IS  - 0009-9074 (Linking)
VI  - 158
IP  - 2
DP  - 2007 Mar-Apr
TI  - [Gastroesophageal reflux disease: therapeutic features (Part II)].
PG  - 165-72
AB  - Gastroesophageal reflux disease (GERD) can be defined as a condition resulting 
      from the reflux of stomach contents into the esophagus. Its pharmacological 
      treatment is aimed at symptom relief, healing of erosions and ulcerations and 
      prevention of relapses. Based on the pathophysiology, the ideal treatment is 
      directed to enhance basal sphincter pressure or decrease the frequency of TLESR, 
      restore esophageal "clearance", accelerate gastric emptying and highten mucosal 
      resistance as well as reduce or inhibit gastric acid secretion. Most of these 
      targets are currently achievable because the availability of different types of 
      drugs, however the "ideal" pharmacologic treatment of GERD does not exist. 
      Current remedies for GERD include life style changes along with a wide array of 
      antisecretory drugs, such as antacids, H2-antagonists and proton pump inhibitors 
      (PPI). Surgery, based on anti-reflux procedures, and endoscopic approaches may 
      have a role in the management of patients with GERD.
FAU - Corinaldesi, R
AU  - Corinaldesi R
AD  - Dipartimento di Medicina Interna e Gastroenterologia, Universita degli Studi di 
      Bologna, Italia. robecori@med.unibo.it
FAU - Salvioli, B
AU  - Salvioli B
FAU - Lioce, A
AU  - Lioce A
FAU - Barbara, G
AU  - Barbara G
FAU - Cremon, C
AU  - Cremon C
FAU - Fustini, E
AU  - Fustini E
FAU - Bini, L
AU  - Bini L
FAU - Cogliandro, R
AU  - Cogliandro R
FAU - Boschi, E
AU  - Boschi E
FAU - Felicani, C
AU  - Felicani C
FAU - Stanghellini, V
AU  - Stanghellini V
FAU - De Giorgio, R
AU  - De Giorgio R
LA  - ita
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - La malattia da reflusso gastro-esofageo: aspetti terapeutici (Parte II).
PL  - Italy
TA  - Clin Ter
JT  - La Clinica terapeutica
JID - 0372604
SB  - IM
MH  - Gastroesophageal Reflux/drug therapy/surgery/*therapy
MH  - Humans
RF  - 70
EDAT- 2007/06/15 09:00
MHDA- 2007/09/08 09:00
CRDT- 2007/06/15 09:00
PHST- 2007/06/15 09:00 [pubmed]
PHST- 2007/09/08 09:00 [medline]
PHST- 2007/06/15 09:00 [entrez]
PST - ppublish
SO  - Clin Ter. 2007 Mar-Apr;158(2):165-72.