PMID- 17567943
OWN - NLM
STAT- MEDLINE
DCOM- 20071227
LR  - 20181201
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1112
DP  - 2007 Sep
TI  - Signaling pathways leading to the activation of IKK and MAPK by thymosin alpha1.
PG  - 339-50
AB  - Thymosin alpha 1 (Talpha1) has therapeutic potential in the treatment of 
      infectious diseases and cancer. However, the exact molecular pathways for Talpha1 
      action are not fully understood. We found that Talpha1 induces the production of 
      interleukin-6 (IL-6), IL-10, and IL-12 in murine bone marrow-derived macrophages 
      (BMDMs) through IKK and MAPK pathways. Talpha1 triggers the activation of AP-1 
      and the phosphorylation of JNK and p38. Inhibition of p38 impairs IL-6 production 
      in response to Talpha1. Further, TRAF6 is involved in the activation of JNK and 
      IRAK4 is involved for the activation of IKK and PKCzeta in a Talpha1-induced 
      system. Loss of IRAK4 largely blocked induction of IL-6. Thus, our studies define 
      early signal events that are critical for the Talpha1-induced immune responses.
FAU - Peng, Xiao
AU  - Peng X
AD  - Department of Molecular Microbiology and Immunology, Brown University, 
      Providence, RI 02912, USA.
FAU - Zhang, Ping
AU  - Zhang P
FAU - Wang, Xin
AU  - Wang X
FAU - Chan, Justin
AU  - Chan J
FAU - Zhu, Mingwei
AU  - Zhu M
FAU - Jiang, Meisheng
AU  - Jiang M
FAU - Tuthill, Cynthia
AU  - Tuthill C
FAU - Wan, Yinsheng
AU  - Wan Y
FAU - Dragoi, Ana Maria
AU  - Dragoi AM
FAU - Chu, Wen-Ming
AU  - Chu WM
LA  - eng
GR  - AI 54128-01/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20070613
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 187348-17-0 (Interleukin-12)
RN  - 61512-21-8 (Thymosin)
RN  - EC 2.7.11.1 (protein kinase C zeta)
RN  - EC 2.7.11.10 (I-kappa B Kinase)
RN  - EC 2.7.11.13 (Protein Kinase C)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - W0B22ISQ1C (Thymalfasin)
SB  - IM
MH  - Dendritic Cells/immunology
MH  - Enzyme Activation
MH  - Humans
MH  - I-kappa B Kinase/*metabolism
MH  - Interleukin-12/metabolism
MH  - Mitogen-Activated Protein Kinases/*metabolism
MH  - Protein Kinase C/metabolism
MH  - Signal Transduction/*physiology
MH  - Thymalfasin
MH  - Thymosin/analogs & derivatives/physiology
EDAT- 2007/06/15 09:00
MHDA- 2007/12/28 09:00
CRDT- 2007/06/15 09:00
PHST- 2007/06/15 09:00 [pubmed]
PHST- 2007/12/28 09:00 [medline]
PHST- 2007/06/15 09:00 [entrez]
AID - annals.1415.025 [pii]
AID - 10.1196/annals.1415.025 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2007 Sep;1112:339-50. doi: 10.1196/annals.1415.025. Epub 2007 
      Jun 13.