PMID- 17568050
OWN - NLM
STAT- MEDLINE
DCOM- 20071220
LR  - 20191210
IS  - 0143-005X (Print)
IS  - 1470-2738 (Electronic)
IS  - 0143-005X (Linking)
VI  - 61
IP  - 7
DP  - 2007 Jul
TI  - Association of serum concentrations of persistent organic pollutants with the 
      prevalence of learning disability and attention deficit disorder.
PG  - 591-6
AB  - OBJECTIVE: Even though persistent organic pollutants (POPs) are well-known 
      neurotoxicants, there is no previous study, even cross-sectional, on the 
      association between background exposure to POPs and clinically significant 
      developmental disorders, such as learning disability (LD) or attention deficit 
      disorder (ADD), among children from a general population. DESIGN: Cross-sectional 
      study. SETTING: Study subjects were 278 children aged 12-15 years included in the 
      National Health and Nutrition Examination Survey 1999-2000. The seven most 
      commonly detected POPs (each detectable in >/=20% of children: 
      3,3',4,4',5-pentachlorobiphenyl; 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin 
      (HPCDD); 1,2,3,4,6,7,8,9-octachlorodibenzo-p-dioxin (OCDD); 
      1,2,3,4,6,7,8-heptachlorodibenzofuran (HPCDF); beta-hexachlorocyclohexane; 
      p,p'-dichlorodiphenyltrichloroethane; and trans-nonachlor) were selected. MAIN 
      RESULTS: Compared with children with non-detectable levels of POPs, adjusted 
      prevalence ORs (95% CIs) of LD among those with detectable levels of HPCDD, OCDD 
      or HPCDF were 2.08 ( 1.17 to 3.68), 2.72 (1.24 to 5.99) and 2.18 (1.15 to 4.15), 
      respectively. For ADD, the corresponding figures were 3.41 (1.08 to 10.8), 3.33 
      (0.94 to 11.8) and 2.31 (0.62 to 8.63), respectively. CONCLUSIONS: Associations 
      were observed between serum concentrations of POPs belonging to the categories of 
      polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans and the 
      prevalence of two clinically significant development problems, LD and ADD. The 
      nature of these associations needs to be clarified by prospective studies.
FAU - Lee, Duk-Hee
AU  - Lee DH
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook University, 101 
      Dongin-dong, Jung-gu, Daegu 700-422, Korea. lee_dh@knu.ac.kr
FAU - Jacobs, David R
AU  - Jacobs DR
FAU - Porta, Miquel
AU  - Porta M
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Epidemiol Community Health
JT  - Journal of epidemiology and community health
JID - 7909766
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
SB  - IM
CIN - J Epidemiol Community Health. 2007 Jul;61(7):564-5. PMID: 17568044
MH  - Adolescent
MH  - Attention Deficit Disorder with Hyperactivity/*epidemiology
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - *Environmental Pollutants/analysis/blood
MH  - Female
MH  - Humans
MH  - Learning Disabilities/*epidemiology
MH  - Male
MH  - Organic Chemicals/*analysis/blood
MH  - United States/epidemiology
PMC - PMC2465758
COIS- Competing interests: None declared.
EDAT- 2007/06/15 09:00
MHDA- 2007/12/21 09:00
PMCR- 2010/07/01
CRDT- 2007/06/15 09:00
PHST- 2007/06/15 09:00 [pubmed]
PHST- 2007/12/21 09:00 [medline]
PHST- 2007/06/15 09:00 [entrez]
PHST- 2010/07/01 00:00 [pmc-release]
AID - 61/7/591 [pii]
AID - ch54700 [pii]
AID - 10.1136/jech.2006.054700 [doi]
PST - ppublish
SO  - J Epidemiol Community Health. 2007 Jul;61(7):591-6. doi: 
      10.1136/jech.2006.054700.