PMID- 17568789
OWN - NLM
STAT- MEDLINE
DCOM- 20071126
LR  - 20151119
IS  - 1466-4879 (Print)
IS  - 1466-4879 (Linking)
VI  - 8
IP  - 6
DP  - 2007 Sep
TI  - Distinctive gene expression signatures in rheumatoid arthritis synovial tissue 
      fibroblast cells: correlates with disease activity.
PG  - 480-91
AB  - Gene expression profiling of rheumatoid arthritis (RA) and osteoarthritis (OA) 
      joint tissue samples provides a unique insight into the gene signatures involved 
      in disease development and progression. Fibroblast-like synovial (FLS) cells were 
      obtained from RA, OA and control trauma joint tissues (non-RA, non-OA) and RNA 
      was analyzed by Affymetrix microarray. Thirty-four genes specific to RA and OA 
      FLS cells were identified (P<0.05). HOXD10, HOXD11, HOXD13, CCL8 and LIM homeobox 
      2 were highly and exclusively expressed in RA and CLU, sarcoglycan-gamma, GPR64, 
      POU3F3, peroxisome proliferative activated receptor-gamma and tripartite 
      motif-containing 2 were expressed only in OA. The data also revealed expression 
      heterogeneity for patients with the same disease. To address disease 
      heterogeneity in RA FLS cells, we examined the effects of clinical disease 
      parameters (Health Assessment Questionnaire (HAQ) score, C-reactive protein 
      (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF)) and drug 
      therapies (methotrexate/prednisone) on RA FLS cell gene expression. Eight 
      specific and unique correlations were identified: human leukocyte antigen 
      (HLA)-DQA2 with HAQ score; Clec12A with RF; MAB21L2, SIAT7E, HAPLN1 and BAIAP2L1 
      with CRP level; RGMB and OSAP with ESR. Signature RA FLS cell gene expression 
      profiles may provide insights into disease pathogenesis and have utility in 
      diagnosis, prognosis and drug responsiveness.
FAU - Galligan, C L
AU  - Galligan CL
AD  - Toronto General Research Institute, University Health Network, Toronto, Ontario, 
      Canada.
FAU - Baig, E
AU  - Baig E
FAU - Bykerk, V
AU  - Bykerk V
FAU - Keystone, E C
AU  - Keystone EC
FAU - Fish, E N
AU  - Fish EN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070614
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 9009-79-4 (Rheumatoid Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/drug therapy/*genetics/*physiopathology
MH  - Blood Sedimentation
MH  - C-Reactive Protein/genetics/metabolism
MH  - Cells, Cultured
MH  - Disease Progression
MH  - Female
MH  - Fibroblasts/*metabolism
MH  - *Gene Expression Profiling
MH  - Humans
MH  - Joints
MH  - Male
MH  - Middle Aged
MH  - Oligonucleotide Array Sequence Analysis
MH  - Osteoarthritis/drug therapy/genetics/metabolism/physiopathology
MH  - Rheumatoid Factor/genetics/metabolism
MH  - Surveys and Questionnaires
MH  - Synovial Membrane/*metabolism/pathology
EDAT- 2007/06/15 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/06/15 09:00
PHST- 2007/06/15 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/06/15 09:00 [entrez]
AID - 6364400 [pii]
AID - 10.1038/sj.gene.6364400 [doi]
PST - ppublish
SO  - Genes Immun. 2007 Sep;8(6):480-91. doi: 10.1038/sj.gene.6364400. Epub 2007 Jun 
      14.