PMID- 17569679
OWN - NLM
STAT- MEDLINE
DCOM- 20080227
LR  - 20151119
IS  - 0195-668X (Print)
IS  - 0195-668X (Linking)
VI  - 28
IP  - 14
DP  - 2007 Jul
TI  - The potential to improve primary prevention in the future by using BNP/N-BNP as 
      an indicator of silent 'pancardiac' target organ damage: BNP/N-BNP could become 
      for the heart what microalbuminuria is for the kidney.
PG  - 1678-82
AB  - Brain natriuretic peptide (BNP) or N-terminal pro-BNP (N-BNP) now appears to be 
      the best independent predictor of cardiovascular mortality over and above the 
      conventional ones like blood pressure. This may be because a high BNP/N-BNP is 
      identifying any form of asymptomatic cardiac target organ damage (TOD) 
      [especially silent ischaemia, left ventricular hypertrophy (LVH), left atrial 
      dilatation/atrial fibrillation (LAD/AF) and LV systolic dysfunction (LVSD)]. 
      There are strong hints that BNP/N-BNP will also identify those who are going to 
      develop LVH, LAD/AF, and LVSD in a few years' time. Thus, the prospects are good 
      that BNP/N-BNP could be used to identify 'pancardiac' TOD, even when it is silent 
      and that this information could be 'harnessed' to improve primary prevention. 
      BNP/N-BNP could become to the heart what microalbuminuria is to the kidneys, i.e. 
      an indicator of early, silent TOD.
FAU - Struthers, Allan
AU  - Struthers A
AD  - Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, 
      University of Dundee, Dundee, UK. a.d.struthers@dundee.ac.uk
FAU - Lang, Chim
AU  - Lang C
LA  - eng
PT  - Journal Article
DEP - 20070614
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
RN  - 0 (Biomarkers)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Biomarkers/blood
MH  - Death, Sudden, Cardiac/*prevention & control
MH  - Heart Failure/*etiology/mortality
MH  - Humans
MH  - Natriuretic Peptide, Brain/*blood
MH  - Predictive Value of Tests
MH  - Primary Prevention/methods
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sensitivity and Specificity
EDAT- 2007/06/16 09:00
MHDA- 2008/02/28 09:00
CRDT- 2007/06/16 09:00
PHST- 2007/06/16 09:00 [pubmed]
PHST- 2008/02/28 09:00 [medline]
PHST- 2007/06/16 09:00 [entrez]
AID - ehm234 [pii]
AID - 10.1093/eurheartj/ehm234 [doi]
PST - ppublish
SO  - Eur Heart J. 2007 Jul;28(14):1678-82. doi: 10.1093/eurheartj/ehm234. Epub 2007 
      Jun 14.