PMID- 17569735
OWN - NLM
STAT- MEDLINE
DCOM- 20071030
LR  - 20181113
IS  - 0022-3751 (Print)
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Linking)
VI  - 583
IP  - Pt 1
DP  - 2007 Aug 15
TI  - Developmental changes in brain-derived neurotrophic factor-mediated modulations 
      of synaptic activities in the pontine Kolliker-Fuse nucleus of the rat.
PG  - 315-27
AB  - The Kolliker-Fuse nucleus (KF), part of the respiratory network, is involved in 
      the modulation of respiratory phase durations in response to peripheral and 
      central afferent inputs. The KF is immature at birth. Developmental changes in 
      its physiological and anatomical properties have yet to be investigated. Since 
      brain-derived neurotrophic factor (BDNF) is of major importance for the 
      maturation of neuronal networks, we investigated its effects on developmental 
      changes in the KF on different postnatal days (neonatal, P1-5; intermediate, 
      P6-13; juvenile, P14-21) by analysing single neurones in the in vitro slice 
      preparation and network activities in the perfused brainstem preparation in situ. 
      The BDNF had only weak effects on the frequency of mixed excitatory and 
      inhibitory spontaneous postsynaptic currents (sPSCs) in neonatal slice 
      preparations. Postnatally, in the intermediate and juvenile age groups, a 
      significant augmentation of the sPSC frequency was observed in the presence of 
      100 pm BDNF (+23.5+/-12.6 and +76.7+/-28.4%, respectively). Subsequent analyses 
      of BDNF effects on evoked excitatory postsynaptic currents (eEPSCs) revealed 
      significant enhancement of eEPSC amplitude of +20.8+/-7.0% only in juvenile 
      stages (intermediates, -13.2+/-4.8%). On the network level, significant 
      modulation of phrenic nerve activity following BDNF microinjection into the KF 
      was also observed only in juveniles. The data suggest that KF neurones are 
      subject to BDNF-mediated fast synaptic modulation after completion of postnatal 
      maturation. After maturation, BDNF contributes to modulation of fast excitatory 
      neurotransmission in respiratory-related KF neurones. This may be important for 
      network plasticity associated with the processing of afferent information.
FAU - Kron, Miriam
AU  - Kron M
AD  - Department of Neuro and Sensory Physiology, University Medical Center Gottingen, 
      Georg-August-University, Humboldtallee 23, 37073 Gottingen, Germany.
FAU - Morschel, Michael
AU  - Morschel M
FAU - Reuter, Julia
AU  - Reuter J
FAU - Zhang, Weiqi
AU  - Zhang W
FAU - Dutschmann, Mathias
AU  - Dutschmann M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070614
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Excitatory Postsynaptic Potentials/physiology
MH  - Female
MH  - Male
MH  - Microinjections
MH  - Neurons/cytology/drug effects/physiology
MH  - Phrenic Nerve/drug effects/physiology
MH  - Pons/*growth & development/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Respiratory Physiological Phenomena
MH  - Synapses/drug effects/*physiology
PMC - PMC2277243
EDAT- 2007/06/16 09:00
MHDA- 2007/10/31 09:00
PMCR- 2008/08/15
CRDT- 2007/06/16 09:00
PHST- 2007/06/16 09:00 [pubmed]
PHST- 2007/10/31 09:00 [medline]
PHST- 2007/06/16 09:00 [entrez]
PHST- 2008/08/15 00:00 [pmc-release]
AID - jphysiol.2007.134726 [pii]
AID - 10.1113/jphysiol.2007.134726 [doi]
PST - ppublish
SO  - J Physiol. 2007 Aug 15;583(Pt 1):315-27. doi: 10.1113/jphysiol.2007.134726. Epub 
      2007 Jun 14.