PMID- 17570998
OWN - NLM
STAT- MEDLINE
DCOM- 20070814
LR  - 20220409
IS  - 1057-0829 (Print)
IS  - 1057-0829 (Linking)
VI  - 16
IP  - 4
DP  - 2007 Jun-Jul
TI  - Prevalence of open-angle glaucoma, glaucoma suspect, and ocular hypertension in 
      thyroid-related immune orbitopathy.
PG  - 358-62
AB  - PURPOSE: To determine the prevalence of open-angle glaucoma (OAG), glaucoma 
      suspects (GS), and ocular hypertension (OHT) in patients with thyroid-related 
      immune orbitopathy (TRIO) and compare it with a control group. PATIENTS AND 
      METHODS: In this cross-sectional analytic study, 233 eyes of 117 patients with 
      TRIO (case group) and 240 eyes of 120 normal age and sex-matched individuals 
      (control group) underwent complete ocular examinations. Grave orbitopathy (GO) 
      was diagnosed by clinical examinations with the help of an endocrinologist and 
      para clinic tests. Controls were selected among apparently healthy individuals 
      with no history of previous orbitopathy or thyroid diseases. RESULTS: Prevalence 
      of OAG and OHT was 2.5% and 8.5% in the case group, respectively. In contrast, 
      OAG was detected in only 2 eyes (0.8%) of the control group and there were no 
      instances of GS or OHT in the control group. Although the prevalence of OAG and 
      GS were higher in cases than controls, this difference was not statistically 
      significant. However, OHT was more common in cases (P<0.01). Ten eyes in the case 
      group (4.3%) developed compressive optic neuropathy (CON); high intraocular 
      pressure was detected in 5 of them (2.1%). All cases of OAG and GS in the case 
      group were classified as stage 3 or higher of No symptoms or signs, Only signs no 
      symptoms, Soft tissue, Proptosis, Extraocular muscle, Cornea, Sight loss. Active 
      GO was only more prevalent in patients with OHT (P<0.001). CONCLUSIONS: The 
      prevalence of OHT was higher in cases with GO than age and sex-matched controls. 
      Ophthalmologic examinations including intraocular pressure measurement (and if 
      needed automated visual fields) should be regularly performed in patients with GO 
      particularly in higher stages and those with active disease.
FAU - Behrouzi, Zohreh
AU  - Behrouzi Z
AD  - Department of Ophthalmology, Imam Hossein Hospital, Ophthalmic Research Center, 
      Tehran, Iran.
FAU - Rabei, Hossein Mohammad
AU  - Rabei HM
FAU - Azizi, Fereidoon
AU  - Azizi F
FAU - Daftarian, Narsis
AU  - Daftarian N
FAU - Mehrabi, Yadollah
AU  - Mehrabi Y
FAU - Ardeshiri, Maryam
AU  - Ardeshiri M
FAU - Mohammadpour, Mehrdad
AU  - Mohammadpour M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Glaucoma
JT  - Journal of glaucoma
JID - 9300903
SB  - IM
CIN - J Glaucoma. 2008 Apr-May;17(3):249; author reply 249-50. PMID: 18414116
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glaucoma, Open-Angle/diagnosis/*epidemiology
MH  - Graves Ophthalmopathy/diagnosis/*epidemiology
MH  - Humans
MH  - *Intraocular Pressure
MH  - Iran/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Ocular Hypertension/diagnosis/epidemiology
MH  - Prevalence
EDAT- 2007/06/16 09:00
MHDA- 2007/08/19 09:00
CRDT- 2007/06/16 09:00
PHST- 2007/06/16 09:00 [pubmed]
PHST- 2007/08/19 09:00 [medline]
PHST- 2007/06/16 09:00 [entrez]
AID - 00061198-200706000-00003 [pii]
AID - 10.1097/IJG.0b013e31802e644b [doi]
PST - ppublish
SO  - J Glaucoma. 2007 Jun-Jul;16(4):358-62. doi: 10.1097/IJG.0b013e31802e644b.