PMID- 17572889
OWN - NLM
STAT- MEDLINE
DCOM- 20080219
LR  - 20220310
IS  - 0301-0449 (Print)
IS  - 0301-0449 (Linking)
VI  - 37
IP  - 10
DP  - 2007 Oct
TI  - Neuroimaging of herpesvirus infections in children.
PG  - 949-63
AB  - Six members of the herpesvirus family cause well-described neurologic disease in 
      children: herpes simplex virus-1 (HSV-1), herpes simplex virus-2 (HSV-2), 
      varicella-zoster (VZV), Epstein-Barr (EBV), cytomegalovirus (CMV), and human 
      herpes virus-6 (HHV-6). When herpesviruses infect the central nervous system 
      (CNS), the clinical presentation is non-specific and often confounding. The 
      clinical urgency is often underscored by progressive neurologic deficits, 
      seizures, or even death, and prompt diagnosis and treatment rely heavily on 
      neuroimaging. This review focuses on the spectrum of cerebral manifestations 
      caused by these viruses, particularly on non-congenital presentations. Recent 
      advances in our understanding of these viruses are discussed, including new 
      polymerase chain reaction techniques that allow parallel detection, which has 
      improved our recognition that the herpesviruses are neurotropic and involve the 
      CNS more often than previously thought. Evolving knowledge has also better 
      elucidated viral neuropathology, particularly the role of VZV vasculitis in the 
      brain, HHV-6 in febrile seizures, and herpesvirus reactivation in 
      immunosuppressed patients. The virology, clinical course, and CNS manifestations 
      of each virus are reviewed, followed by descriptions of neuroimaging findings 
      when these agents infect the brain. Characteristic but often subtle imaging 
      findings are discussed, as well as technical pearls covering appropriate use of 
      MRI and MRI adjuncts to help differentiate viral infection from mimics.
FAU - Baskin, Henry J
AU  - Baskin HJ
AD  - Department of Radiology, Cincinnati Children's Medical Center, 3333 Burnet Ave., 
      Cincinnati, OH 45229-3039, USA. baskinhj@gmail.com
FAU - Hedlund, Gary
AU  - Hedlund G
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20070522
PL  - Germany
TA  - Pediatr Radiol
JT  - Pediatric radiology
JID - 0365332
SB  - IM
CIN - Pediatr Radiol. 2008 Mar;38(3):354-5. PMID: 18231787
MH  - Brain/*pathology/*virology
MH  - Diagnosis, Differential
MH  - Encephalitis Viruses
MH  - Encephalitis, Viral/*diagnosis/*virology
MH  - Herpesviridae Infections/*diagnosis/*virology
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
RF  - 26
EDAT- 2007/06/19 09:00
MHDA- 2008/02/20 09:00
CRDT- 2007/06/19 09:00
PHST- 2007/01/31 00:00 [received]
PHST- 2007/04/10 00:00 [accepted]
PHST- 2007/03/20 00:00 [revised]
PHST- 2007/06/19 09:00 [pubmed]
PHST- 2008/02/20 09:00 [medline]
PHST- 2007/06/19 09:00 [entrez]
AID - 10.1007/s00247-007-0506-1 [doi]
PST - ppublish
SO  - Pediatr Radiol. 2007 Oct;37(10):949-63. doi: 10.1007/s00247-007-0506-1. Epub 2007 
      May 22.