PMID- 17573238
OWN - NLM
STAT- MEDLINE
DCOM- 20070918
LR  - 20080910
IS  - 1388-2457 (Print)
IS  - 1388-2457 (Linking)
VI  - 118
IP  - 8
DP  - 2007 Aug
TI  - Alteration of motor nerve recovery cycle in multiple sclerosis.
PG  - 1753-8
AB  - OBJECTIVE: To study peripheral motor nerve excitability in patients with multiple 
      sclerosis (MS). METHODS: Twenty MS patients with normal nerve conduction 
      parameters and no predisposing factors for peripheral neuropathy were included. 
      Compound muscle action potentials were recorded from the abductor digiti minimi 
      muscle to paired-pulse stimulation of the ulnar nerve at the wrist, with various 
      interstimuli intervals (ISIs) ranging from 1 to 7 ms. The motor nerve recovery 
      cycle was studied using a subtraction method. We measured the durations of the 
      absolute and relative refractory periods (ARP, RRP) and the percentages of 
      refractoriness and supernormality at 2.6 and 7 ms ISIs. The results obtained in 
      MS patients were compared to normative values established in 20 age-matched 
      healthy subjects. Correlations were made between excitability parameters and MS 
      type (relapsing-remitting or progressive), EDSS score, disease duration, and 
      motor evoked potential (MEP) abnormalities. RESULTS: Supernormality was extremely 
      reduced, refractoriness was increased and both ARP and RRP were prolonged in MS 
      patients vs. healthy controls. These alterations did not correlate to clinical 
      features or to the presence of MEP abnormalities. CONCLUSIONS: Changes in motor 
      nerve recovery cycle revealed the existence of subtle impairment in the 
      peripheral nervous system of MS patients, mainly characterized by a reduced 
      supernormality. SIGNIFICANCE: Peripheral nerve excitability alterations in MS may 
      be due to axoglial paranodal dysjunction or juxtaparanodal dysfunction.
FAU - Boerio, Delphine
AU  - Boerio D
AD  - Service de Physiologie, Explorations Fonctionnelles, Hopital Henri Mondor, AP-HP, 
      51 avenue de Lattre de Tassigny, 94010 Creteil cedex, France.
FAU - Creange, Alain
AU  - Creange A
FAU - Hogrel, Jean-Yves
AU  - Hogrel JY
FAU - Lefaucheur, Jean-Pascal
AU  - Lefaucheur JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070618
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Action Potentials
MH  - Adult
MH  - Aged
MH  - Disability Evaluation
MH  - Electric Stimulation
MH  - Evoked Potentials, Motor
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Motor Neurons
MH  - Multiple Sclerosis, Chronic Progressive/*physiopathology
MH  - Multiple Sclerosis, Relapsing-Remitting/*physiopathology
MH  - Muscle, Skeletal/physiopathology
MH  - *Refractory Period, Electrophysiological
MH  - Ulnar Nerve/*physiopathology
MH  - Wrist/innervation
EDAT- 2007/06/19 09:00
MHDA- 2007/09/19 09:00
CRDT- 2007/06/19 09:00
PHST- 2007/02/05 00:00 [received]
PHST- 2007/04/04 00:00 [revised]
PHST- 2007/04/30 00:00 [accepted]
PHST- 2007/06/19 09:00 [pubmed]
PHST- 2007/09/19 09:00 [medline]
PHST- 2007/06/19 09:00 [entrez]
AID - S1388-2457(07)00191-5 [pii]
AID - 10.1016/j.clinph.2007.04.025 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2007 Aug;118(8):1753-8. doi: 10.1016/j.clinph.2007.04.025. 
      Epub 2007 Jun 18.