PMID- 17573415
OWN - NLM
STAT- MEDLINE
DCOM- 20071026
LR  - 20141120
IS  - 0958-0670 (Print)
IS  - 0958-0670 (Linking)
VI  - 92
IP  - 5
DP  - 2007 Sep
TI  - Comparative study of NMDA and AMPA/kainate receptors involved in cardiovascular 
      inhibition produced by imidazoline-like drugs in anaesthetized rats.
PG  - 849-58
AB  - The depressor mechanism of imidazoline-like drugs is believed to result from 
      activation of I(1)-imidazoline receptors (I(1)R) and/or alpha(2)-adrenoceptors 
      within the central nervous system, which are associated with the glutamatergic 
      system. The rostral ventrolateral medulla (RVLM) has been recognized as a 
      specific target area that mediates the depressor action of imidazoline-like 
      drugs. The objective of this study was to determine the comparative effects of 
      blockade of the central glutamate receptor subtypes N-methyl-d-aspartate (NMDA) 
      or alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate on the 
      cardiovascular actions of imidazoline-like drugs (clonidine and moxonidine) in 
      anaesthetized rats. Intracerebroventricular (i.c.v.) injection of the NMDA 
      receptor antagonist MK801 or the AMPA/kainate receptor antagonist 
      6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) produced similar reductions in blood 
      pressure (BP) and heart rate (HR) to those induced by I.C.V. injection of 
      clonidine. Intracerebroventricular injection of the glutamate receptor antagonist 
      kynurenic acid not only abolished clonidine-induced hypotension and bradycardia 
      but converted the responses to a pressor action and tachycardia. Unilateral 
      injection of MK801 or CNQX into RVLM significantly attenuated intra-RVLM 
      clonidine-induced decreases in BP and HR. We also found that unilateral injection 
      of a selective I(1)R agonist, moxonidine, significantly decreased BP and HR, 
      which were also attenuated to a similar extent by prior injection of MK801 or 
      CNQX. In conclusion, these data show that blockade of central (RVLM) NMDA and 
      AMPA/kainate receptors produces similar attenuation of the decrease in BP and HR 
      induced by clonidine or moxonidine. It is suggested that both NMDA and 
      AMPA/kainate receptors are involved in the cardiovascular inhibition produced by 
      imidazoline-like drugs, which is probably at least partly dependent on an I(1)R 
      mechanism in the RVLM.
FAU - Wang, Li-Gang
AU  - Wang LG
AD  - Department of Physiology, Second Military Medical University, 800 Xiang-Yin Road, 
      Shanghai 200433, China.
FAU - Zeng, Jun
AU  - Zeng J
FAU - Yuan, Wen-Jun
AU  - Yuan WJ
FAU - Su, Ding-Feng
AU  - Su DF
FAU - Wang, Wei-Zhong
AU  - Wang WZ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070615
PL  - England
TA  - Exp Physiol
JT  - Experimental physiology
JID - 9002940
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Imidazoles)
RN  - 0 (Imidazoline Receptors)
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, Drug)
RN  - 0 (Receptors, Glutamate)
RN  - 0 (Receptors, Kainic Acid)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - 6OTE87SCCW (6-Cyano-7-nitroquinoxaline-2,3-dione)
RN  - CC6X0L40GW (moxonidine)
RN  - H030S2S85J (Kynurenic Acid)
RN  - MN3L5RMN02 (Clonidine)
SB  - IM
MH  - 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology
MH  - Anesthesia
MH  - Animals
MH  - Antihypertensive Agents/*pharmacology
MH  - Blood Pressure/*drug effects/physiology
MH  - Clonidine/*pharmacology
MH  - Dizocilpine Maleate/pharmacology
MH  - Drug Interactions
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Heart Rate/*drug effects/physiology
MH  - Imidazoles/pharmacology
MH  - Imidazoline Receptors
MH  - Injections, Intraventricular
MH  - Kynurenic Acid/pharmacology
MH  - Male
MH  - Medulla Oblongata/drug effects/physiology
MH  - Microinjections
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, AMPA/physiology
MH  - Receptors, Drug/agonists
MH  - Receptors, Glutamate/*physiology
MH  - Receptors, Kainic Acid/physiology
MH  - Receptors, N-Methyl-D-Aspartate/physiology
EDAT- 2007/06/19 09:00
MHDA- 2007/10/30 09:00
CRDT- 2007/06/19 09:00
PHST- 2007/06/19 09:00 [pubmed]
PHST- 2007/10/30 09:00 [medline]
PHST- 2007/06/19 09:00 [entrez]
AID - expphysiol.2007.037861 [pii]
AID - 10.1113/expphysiol.2007.037861 [doi]
PST - ppublish
SO  - Exp Physiol. 2007 Sep;92(5):849-58. doi: 10.1113/expphysiol.2007.037861. Epub 
      2007 Jun 15.