PMID- 17573575
OWN - NLM
STAT- MEDLINE
DCOM- 20070927
LR  - 20070618
IS  - 0001-6489 (Print)
IS  - 0001-6489 (Linking)
VI  - 127
IP  - 7
DP  - 2007 Jul
TI  - Search for Herpesviruses in cerebrospinal fluid of facial palsy patients by PCR.
PG  - 775-9
AB  - CONCLUSIONS: Herpes simplex virus 1 (HSV-1) and varicella-zoster virus (VZV) DNA 
      were not detected in the cerebrospinal fluid (CSF) of patients with acute 
      idiopathic peripheral facial palsy (Bell's palsy). Our results indicate either 
      the absence of these viruses or the presence of technical shortcomings. The role 
      of human herpesvirus 6 (HHV-6) in this disorder and the significance of a 
      positive HHV-6 DNA finding in the central nervous system need further 
      investigation. OBJECTIVE: Our goal was to determine whether DNA of HSV-1, VZV, or 
      HHV-6 can be found by polymerase chain reaction (PCR) in the CSF of peripheral 
      facial palsy patients. MATERIALS AND METHODS: We used PCR to detect the presence 
      of HSV-1, VZV, and HHV-6 DNA in CSF. This was a retrospective case control study 
      with 33 peripheral facial palsy patients (34 CSF samples) in the study group (26 
      with Bell's palsy, 5 with simultaneously diagnosed herpesvirus infection, 1 with 
      puerperal facial palsy, 1 with Melkersson-Rosenthal syndrome). The control group 
      included 36 patients, most with diagnosed or suspected Borreliosis and facial 
      palsy or sudden deafness. RESULTS: One patient with Bell's palsy had HHV-6 DNA in 
      CSF. Neither HSV-1 nor VZV DNA was detected in patients or controls.
FAU - Kanerva, Mervi
AU  - Kanerva M
AD  - Department of Otorhinolaryngology, Helsinki University Central Hospital, 
      Helsinki, Finland. mervi.kanerva@fimnet.fi
FAU - Mannonen, Laura
AU  - Mannonen L
FAU - Piiparinen, Heli
AU  - Piiparinen H
FAU - Peltomaa, Miikka
AU  - Peltomaa M
FAU - Vaheri, Antti
AU  - Vaheri A
FAU - Pitkaranta, Anne
AU  - Pitkaranta A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Bell Palsy/*virology
MH  - Case-Control Studies
MH  - Child
MH  - DNA, Viral/*cerebrospinal fluid
MH  - Facial Paralysis/*virology
MH  - Female
MH  - Herpesviridae/*genetics/isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Retrospective Studies
EDAT- 2007/06/19 09:00
MHDA- 2007/09/28 09:00
CRDT- 2007/06/19 09:00
PHST- 2007/06/19 09:00 [pubmed]
PHST- 2007/09/28 09:00 [medline]
PHST- 2007/06/19 09:00 [entrez]
AID - 779592272 [pii]
AID - 10.1080/00016480601011444 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2007 Jul;127(7):775-9. doi: 10.1080/00016480601011444.