PMID- 17573720
OWN - NLM
STAT- MEDLINE
DCOM- 20070905
LR  - 20070618
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 62
IP  - 7
DP  - 2007 Jul
TI  - Diagnostic accuracy of the atopy patch test in children with food allergy-related 
      gastrointestinal symptoms.
PG  - 738-43
AB  - BACKGROUND: Little is known about the diagnostic accuracy of atopy patch tests 
      (APT) in the clinical practice of pediatric gastroenterology. Moreover, APTs 
      containing purified food extracts have recently become available, but their 
      diagnostic accuracy is largely undefined. PATIENTS AND METHODS: We evaluated the 
      diagnostic accuracy of food challenge, skin prick test (SPT), serum specific IgE 
      determination, and APT using fresh food and commercial food extracts in parallel 
      in children referred for suspected food allergy-related gastrointestinal 
      symptoms. RESULTS: Eighty-nine food challenges were performed in 60 patients (38 
      boys, median age 23 months, range 3-48 months): 31 tested positive for cow's milk 
      (CM), 19 for hen's egg (HE), and two for wheat. Specific immunoglobulin E (IgE) 
      determination, and SPT, respectively, were positive in 7/31 and 14/31 of patients 
      with cow's milk allergy (CMA), and in 7/19 and 7/19 with HE allergy. The results 
      of APT with fresh food vs a commercial assay were (1) CM: sensitivity: 64.5%vs 
      6.4%, specificity 95.8%vs 95.6%, positive predictive value (PPV) 95.2%vs 66.6% 
      and negative predictive value (NPV) 67.6%vs 43.1%; (2) HE: sensitivity 84.2%vs 
      5.2%, specificity 100%vs 100%, PPV 100%vs 100% and NPV 75.0%vs 33.3%. 
      CONCLUSIONS: Atopy patch test is a useful tool in the diagnostic work up of 
      children with food-allergy-related gastrointestinal symptoms. The diagnostic 
      accuracy of ATP was higher with fresh food than with commercial food extracts.
FAU - Canani, R Berni
AU  - Canani RB
AD  - Department of Pediatrics and European Laboratory for the Investigation of Food 
      Induced Diseases, University of Naples Federico II, Naples, Italy.
FAU - Ruotolo, S
AU  - Ruotolo S
FAU - Auricchio, L
AU  - Auricchio L
FAU - Caldore, M
AU  - Caldore M
FAU - Porcaro, F
AU  - Porcaro F
FAU - Manguso, F
AU  - Manguso F
FAU - Terrin, G
AU  - Terrin G
FAU - Troncone, R
AU  - Troncone R
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Child
MH  - Child, Preschool
MH  - Egg Hypersensitivity/diagnosis
MH  - Female
MH  - Food Hypersensitivity/*complications
MH  - Food Preservation
MH  - Gastrointestinal Diseases/*etiology
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Infant
MH  - Male
MH  - Milk Hypersensitivity/diagnosis
MH  - Patch Tests/*standards
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Wheat Hypersensitivity/diagnosis
EDAT- 2007/06/19 09:00
MHDA- 2007/09/06 09:00
CRDT- 2007/06/19 09:00
PHST- 2007/06/19 09:00 [pubmed]
PHST- 2007/09/06 09:00 [medline]
PHST- 2007/06/19 09:00 [entrez]
AID - ALL1351 [pii]
AID - 10.1111/j.1398-9995.2007.01351.x [doi]
PST - ppublish
SO  - Allergy. 2007 Jul;62(7):738-43. doi: 10.1111/j.1398-9995.2007.01351.x.