PMID- 17574919
OWN - NLM
STAT- MEDLINE
DCOM- 20071001
LR  - 20081121
IS  - 1471-4914 (Print)
IS  - 1471-4914 (Linking)
VI  - 13
IP  - 7
DP  - 2007 Jul
TI  - Bone marrow cell-mediated cardiovascular repair: potential of combined therapies.
PG  - 278-86
AB  - Recent evidence indicates that bone-marrow cells (BMCs) can contribute to the 
      healing process of the injured cardiovascular system via the chemokine receptor 
      CXCR4/SDF-1, thymosin beta(4) and integrin alpha(4)beta(1) molecular pathways. 
      During tissue ischemia overwhelming numbers of detrimental oxygen radicals are 
      generated, and therefore treatment with antioxidants and L-arginine, the 
      precursor of nitric oxide (NO), could induce beneficial effects beyond those 
      achieved by BMC transplantation alone. Recent studies have reported that BMCs 
      have enhanced neovascularization capacity in cotreatment with alpha-tocopherol 
      (vitamin E), ascorbic acid (vitamin C) and L-arginine. Moreover, BMC therapy can 
      be combined with gene therapy. Clinical trials employing BMCs in the treatment of 
      cardiovascular diseases have been completed with mixed or positive results, and 
      several trials are ongoing. Here, we discuss the clinical potential of BMC 
      transplantation alone and in combined therapy that aims to restore organ 
      vascularization and function. We also consider the mechanisms of mobilization, 
      differentiation and incorporation of BMCs.
FAU - Napoli, Claudio
AU  - Napoli C
AD  - Department of General Pathology, Division of Clinical Pathology and Excellence 
      Research Center on Cardiovascular Diseases, 1st School of Medicine, II University 
      of Naples, Italy. claunap@tin.it
FAU - Maione, Ciro
AU  - Maione C
FAU - Schiano, Concetta
AU  - Schiano C
FAU - Fiorito, Carmela
AU  - Fiorito C
FAU - Ignarro, Louis J
AU  - Ignarro LJ
LA  - eng
PT  - Journal Article
DEP - 20070615
PL  - England
TA  - Trends Mol Med
JT  - Trends in molecular medicine
JID - 100966035
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells/*physiology
MH  - *Bone Marrow Transplantation
MH  - Cardiovascular Diseases/surgery/*therapy
MH  - *Cardiovascular Physiological Phenomena
MH  - Cardiovascular System/metabolism
MH  - Cell Proliferation
MH  - Clinical Trials as Topic
MH  - Combined Modality Therapy
MH  - Humans
MH  - Models, Biological
MH  - Peripheral Vascular Diseases/therapy
MH  - Regeneration
MH  - Stem Cells/metabolism
MH  - *Wound Healing
EDAT- 2007/06/19 09:00
MHDA- 2007/10/02 09:00
CRDT- 2007/06/19 09:00
PHST- 2006/08/04 00:00 [received]
PHST- 2007/04/26 00:00 [revised]
PHST- 2007/05/25 00:00 [accepted]
PHST- 2007/06/19 09:00 [pubmed]
PHST- 2007/10/02 09:00 [medline]
PHST- 2007/06/19 09:00 [entrez]
AID - S1471-4914(07)00103-7 [pii]
AID - 10.1016/j.molmed.2007.05.004 [doi]
PST - ppublish
SO  - Trends Mol Med. 2007 Jul;13(7):278-86. doi: 10.1016/j.molmed.2007.05.004. Epub 
      2007 Jun 15.