PMID- 17575482
OWN - NLM
STAT- MEDLINE
DCOM- 20070821
LR  - 20221207
IS  - 1538-4683 (Electronic)
IS  - 1061-5377 (Linking)
VI  - 15
IP  - 4
DP  - 2007 Jul-Aug
TI  - Reversing left ventricular remodeling in chronic heart failure: surgical 
      approaches.
PG  - 184-90
AB  - Chronic heart failure (CHF) has become an epidemic in the United States, with 
      approximately 550,000 new cases annually. With the evolution of pharmacotherapy 
      targeting neurohormonal pathways, the annual mortality in subjects with New York 
      Heart Association (NYHA) class IV CHF has dramatically improved from 52% in the 
      seminal CONSENSUS trial to less than 20% in more recent trials. Suppression of 
      the renin-angiotensin-aldosterone system remains the first line of neurohormonal 
      blockade followed by the addition of selective beta-adrenoreceptor blockers. For 
      patients with NYHA class I and II symptoms, mortality rates have decreased to 
      approximately 5% or less per year with the use of angiotensin-converting enzyme 
      inhibitors, beta-blockers and aldosterone receptor blockers. However, after 
      achieving optimal doses of the indicated pharmacotherapy, and despite the 
      additional benefits obtained with biventricular pacemakers, there are still many 
      patients who continue to experience signs and symptoms of CHF. Recognizing the 
      beneficial effects of the above treatments on left ventricular (LV) remodeling, 
      strategies have been developed to surgically reshape the left ventricle in 
      patients with LV dilation who have associated poor LV function. This review will 
      discuss the techniques and recent developments regarding surgical reshaping of 
      the dilated, dysfunctional, and remodeled left ventricle.
FAU - Ahuja, Kartikya
AU  - Ahuja K
AD  - Heart Failure Center, Leon Charney Division of Cardiology, New York University 
      School of Medicine, New York, New York, USA.
FAU - Crooke, Gregory A
AU  - Crooke GA
FAU - Grossi, Eugene A
AU  - Grossi EA
FAU - Galloway, Aubrey C
AU  - Galloway AC
FAU - Jorde, Ulrich P
AU  - Jorde UP
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cardiol Rev
JT  - Cardiology in review
JID - 9304686
SB  - IM
MH  - Cardiac Surgical Procedures/instrumentation/methods
MH  - Heart Failure/*complications/physiopathology/*surgery
MH  - Heart Ventricles/*surgery
MH  - Heart-Assist Devices
MH  - Humans
MH  - Plastic Surgery Procedures/instrumentation/methods
MH  - Treatment Outcome
MH  - *Ventricular Remodeling
RF  - 44
EDAT- 2007/06/19 09:00
MHDA- 2007/08/22 09:00
CRDT- 2007/06/19 09:00
PHST- 2007/06/19 09:00 [pubmed]
PHST- 2007/08/22 09:00 [medline]
PHST- 2007/06/19 09:00 [entrez]
AID - 00045415-200707000-00004 [pii]
AID - 10.1097/CRD.0b013e318053d13f [doi]
PST - ppublish
SO  - Cardiol Rev. 2007 Jul-Aug;15(4):184-90. doi: 10.1097/CRD.0b013e318053d13f.