PMID- 17576282
OWN - NLM
STAT- MEDLINE
DCOM- 20070810
LR  - 20110520
IS  - 0956-7976 (Print)
IS  - 0956-7976 (Linking)
VI  - 18
IP  - 5
DP  - 2007 May
TI  - Putting feelings into words: affect labeling disrupts amygdala activity in 
      response to affective stimuli.
PG  - 421-8
AB  - Putting feelings into words (affect labeling) has long been thought to help 
      manage negative emotional experiences; however, the mechanisms by which affect 
      labeling produces this benefit remain largely unknown. Recent neuroimaging 
      studies suggest a possible neurocognitive pathway for this process, but 
      methodological limitations of previous studies have prevented strong inferences 
      from being drawn. A functional magnetic resonance imaging study of affect 
      labeling was conducted to remedy these limitations. The results indicated that 
      affect labeling, relative to other forms of encoding, diminished the response of 
      the amygdala and other limbic regions to negative emotional images. Additionally, 
      affect labeling produced increased activity in a single brain region, right 
      ventrolateral prefrontal cortex (RVLPFC). Finally, RVLPFC and amygdala activity 
      during affect labeling were inversely correlated, a relationship that was 
      mediated by activity in medial prefrontal cortex (MPFC). These results suggest 
      that affect labeling may diminish emotional reactivity along a pathway from 
      RVLPFC to MPFC to the amygdala.
FAU - Lieberman, Matthew D
AU  - Lieberman MD
AD  - University of California, Los Angeles, CA 90095-1563, USA. lieber@ucla.edu
FAU - Eisenberger, Naomi I
AU  - Eisenberger NI
FAU - Crockett, Molly J
AU  - Crockett MJ
FAU - Tom, Sabrina M
AU  - Tom SM
FAU - Pfeifer, Jennifer H
AU  - Pfeifer JH
FAU - Way, Baldwin M
AU  - Way BM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Psychol Sci
JT  - Psychological science
JID - 9007542
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Affect/*physiology
MH  - Amygdala/anatomy & histology/*physiology
MH  - Analysis of Variance
MH  - Brain Mapping/methods
MH  - Cues
MH  - Emotions/*physiology
MH  - Facial Expression
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Photic Stimulation/methods
MH  - Prefrontal Cortex/anatomy & histology
MH  - Sex Distribution
MH  - Task Performance and Analysis
MH  - Visual Perception/physiology
EDAT- 2007/06/20 09:00
MHDA- 2007/08/11 09:00
CRDT- 2007/06/20 09:00
PHST- 2007/06/20 09:00 [pubmed]
PHST- 2007/08/11 09:00 [medline]
PHST- 2007/06/20 09:00 [entrez]
AID - PSCI1916 [pii]
AID - 10.1111/j.1467-9280.2007.01916.x [doi]
PST - ppublish
SO  - Psychol Sci. 2007 May;18(5):421-8. doi: 10.1111/j.1467-9280.2007.01916.x.