PMID- 17576512
OWN - NLM
STAT- MEDLINE
DCOM- 20080404
LR  - 20220408
IS  - 0300-9564 (Print)
IS  - 0300-9564 (Linking)
VI  - 114
IP  - 10
DP  - 2007
TI  - Freezing of gait in older adults with high level gait disorders: association with 
      impaired executive function.
PG  - 1349-53
AB  - Freezing of gait (FOG) is frequently observed in high level gait disorders 
      (HLGD), but its relationship to disease progression and cognitive function is 
      unknown. To study this relationship, episodic gait disturbances, affect and 
      cognitive function were assessed in twenty-five patients with HLGD (mean age: 
      78.2 +/- 5.0 yrs). After a mean of 32.2 +/- 4.2 months, twenty-two patients were 
      reassessed. FOG was observed in 20% of the patients at baseline and in 40% at 
      follow-up. The presence of FOG was associated with significant mobility 
      disturbances, functional deterioration as well as poor performance on the frontal 
      neuropsychological assessment battery (Dementia Rating Scale - initiation 
      sub-score) at follow-up. Depression, anxiety and fear of falling were not 
      correlated with the presence of FOG at baseline or follow-up. These results 
      indicate that FOG is common in HLGD, and that it is associated with significant 
      functional disability and a specific frontal cognitive disturbance of initiation.
FAU - Giladi, N
AU  - Giladi N
AD  - Movement Disorders Unit, Department of Neurology, Tel-Aviv Sourasky Medical 
      Center, Tel Aviv, Israel. nirg@tasmc.health.gov.il
FAU - Huber-Mahlin, V
AU  - Huber-Mahlin V
FAU - Herman, T
AU  - Herman T
FAU - Hausdorff, J M
AU  - Hausdorff JM
LA  - eng
GR  - AG-08812/AG/NIA NIH HHS/United States
GR  - AG-14100/AG/NIA NIH HHS/United States
GR  - HD-39838/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070618
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Chi-Square Distribution
MH  - Cognition Disorders/*complications
MH  - Female
MH  - Follow-Up Studies
MH  - Gait Disorders, Neurologic/*complications/*psychology
MH  - *Geriatric Assessment
MH  - Humans
MH  - Male
MH  - Neuropsychological Tests
MH  - Problem Solving/*physiology
EDAT- 2007/06/20 09:00
MHDA- 2008/04/05 09:00
CRDT- 2007/06/20 09:00
PHST- 2007/02/13 00:00 [received]
PHST- 2007/05/22 00:00 [accepted]
PHST- 2007/06/20 09:00 [pubmed]
PHST- 2008/04/05 09:00 [medline]
PHST- 2007/06/20 09:00 [entrez]
AID - 10.1007/s00702-007-0772-y [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2007;114(10):1349-53. doi: 10.1007/s00702-007-0772-y. 
      Epub 2007 Jun 18.