PMID- 17578051
OWN - NLM
STAT- MEDLINE
DCOM- 20070719
LR  - 20140729
IS  - 0966-8519 (Print)
IS  - 0966-8519 (Linking)
VI  - 16
IP  - 3
DP  - 2007 May
TI  - Human leukocyte antigen (HLA) class I and II alleles in Turkish patients with 
      rheumatic heart disease.
PG  - 293-9
AB  - BACKGROUND AND AIM OF THE STUDY: Rheumatic heart disease (RHD) is often preceded 
      by rheumatic fever (RF). The disease is a multisystem inflammatory condition that 
      develops as a sequel to untreated throat infection by group A beta-hemolytic 
      streptococci. Several studies have suggested that genetic susceptibility to RHD 
      may be linked to human leukocyte antigen (HLA) class II alleles. The study aim 
      was to investigate the association between RHD and the antigens HLA-A, -B, -C, 
      -DR and -DQ profile in RHD patients in eastern Turkey. METHODS: A case-control 
      study was conducted which included 85 unrelated patients with RHD, and 85 control 
      subjects. The diagnosis was supported by echocardiography and histories of RHD of 
      those patients who underwent valve replacement. The association of class I and 
      class II HLA antigens was examined in RHD and control subjects using a 
      sequence-specific primer (SSP) method. RESULTS: The phenotypes HLA-B51, -Cw*4 and 
      -DRB1*01 were encountered in significantly lower frequencies in patients with RHD 
      compared to the control population (p <0.05, p <0.05, p <0.05, respectively). 
      There was also a significant increase in antigen frequency of HLA-DQB1*08 in RHD 
      patients compared to controls (p <0.005). CONCLUSION: Among the studied 
      population, the results suggested that susceptibility to RHD was HLA-related, 
      with HLA-DQB1*08 most likely influencing the occurrence of the condition. 
      HLA-B51, -Cw*4 and -DRB1*01 appeared to be more common in control subjects.
FAU - Gundogdu, Fuat
AU  - Gundogdu F
AD  - Department of Cardiology , Aziziye Hospital Faculty of Medicine, Ataturk 
      University, Erzurum, Turkey. gundogdudr@gmail.com
FAU - Islamoglu, Yahya
AU  - Islamoglu Y
FAU - Pirim, Ibrahim
AU  - Pirim I
FAU - Gurlertop, Yekta
AU  - Gurlertop Y
FAU - Dogan, Hasan
AU  - Dogan H
FAU - Arslan, Sakir
AU  - Arslan S
FAU - Sevimli, Serdar
AU  - Sevimli S
FAU - Aksakal, Enbiya
AU  - Aksakal E
FAU - Senocak, Huseyin
AU  - Senocak H
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Heart Valve Dis
JT  - The Journal of heart valve disease
JID - 9312096
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Histocompatibility Antigens Class I/*blood/*genetics
MH  - Histocompatibility Antigens Class II/*blood/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Polymerase Chain Reaction
MH  - Rheumatic Heart Disease/*genetics
MH  - Turkey
EDAT- 2007/06/21 09:00
MHDA- 2007/07/20 09:00
CRDT- 2007/06/21 09:00
PHST- 2007/06/21 09:00 [pubmed]
PHST- 2007/07/20 09:00 [medline]
PHST- 2007/06/21 09:00 [entrez]
PST - ppublish
SO  - J Heart Valve Dis. 2007 May;16(3):293-9.