PMID- 17578530
OWN - NLM
STAT- MEDLINE
DCOM- 20070801
LR  - 20240323
IS  - 0017-8748 (Print)
IS  - 1526-4610 (Electronic)
IS  - 0017-8748 (Linking)
VI  - 47
IP  - 6
DP  - 2007 Jun
TI  - The cerebellum and migraine.
PG  - 820-33
AB  - Clinical and pathophysiological evidences connect migraine and the cerebellum. 
      Literature on documented cerebellar abnormalities in migraine, however, is 
      relatively sparse. Cerebellar involvement may be observed in 4 types of 
      migraines: in the widespread migraine with aura (MWA) and migraine without aura 
      (MWoA) forms; in particular subtypes of migraine such as basilar-type migraine 
      (BTM); and in the genetically driven autosomal dominant familial hemiplegic 
      migraine (FHM) forms. Cerebellar dysfunction in migraineurs varies largely in 
      severity, and may be subclinical. Purkinje cells express calcium channels that 
      are related to the pathophysiology of both inherited forms of migraine and 
      primary ataxias, mostly spinal cerebellar ataxia type 6 (SCA-6) and episodic 
      ataxia type 2 (EA-2). Genetically driven ion channels dysfunction leads to 
      hyperexcitability in the brain and cerebellum, possibly facilitating spreading 
      depression waves in both locations. This review focuses on the cerebellar 
      involvement in migraine, the relevant ataxias and their association with this 
      primary headache, and discusses some of the pathophysiological processes 
      putatively underlying these diseases.
FAU - Vincent, Maurice
AU  - Vincent M
AD  - Hospital Universitario Clementino Fraga Filho, Faculdade de Medicina, 
      Universidade Federal do Rio de Janeiro, Brazil.
FAU - Hadjikhani, Nouchine
AU  - Hadjikhani N
LA  - eng
GR  - P01 NS035611/NS/NINDS NIH HHS/United States
GR  - 5P01 NS 35611-09/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Headache
JT  - Headache
JID - 2985091R
SB  - IM
MH  - Animals
MH  - Ataxia/*physiopathology
MH  - Cerebellum/*physiopathology
MH  - Humans
MH  - Migraine Disorders/classification/*physiopathology
PMC - PMC3761082
MID - NIHMS501945
COIS- Conflict of Interest: None
EDAT- 2007/06/21 09:00
MHDA- 2007/08/02 09:00
PMCR- 2013/09/04
CRDT- 2007/06/21 09:00
PHST- 2007/06/21 09:00 [pubmed]
PHST- 2007/08/02 09:00 [medline]
PHST- 2007/06/21 09:00 [entrez]
PHST- 2013/09/04 00:00 [pmc-release]
AID - HED715 [pii]
AID - 10.1111/j.1526-4610.2006.00715.x [doi]
PST - ppublish
SO  - Headache. 2007 Jun;47(6):820-33. doi: 10.1111/j.1526-4610.2006.00715.x.