PMID- 17579015
OWN - NLM
STAT- MEDLINE
DCOM- 20070807
LR  - 20190516
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 179
IP  - 1
DP  - 2007 Jul 1
TI  - Cutting edge: Antioxidative properties of myeloid dendritic cells: protection of 
      T cells and NK cells from oxygen radical-induced inactivation and apoptosis.
PG  - 21-5
AB  - Dendritic cells (DCs) communicate with nonadaptive and adaptive lymphocytes on 
      multiple levels. Efficient DC-lymphocyte interactions require that lymphocytes 
      remain viable and functional also under conditions of oxidative stress, such as 
      in microbial infection or in the malignant microenvironment. For this study, we 
      exposed human T and NK cells to oxidants delivered either by autologous 
      phagocytes or in the form of exogenous hydrogen peroxide. In accordance with 
      earlier studies, these lymphocytes became dysfunctional and subsequently 
      apoptotic. The presence of myeloid DCs efficiently rescued T cells (CD4+ and 
      CD8+) and NK cells from oxidant-induced inactivation and apoptosis. The mechanism 
      of the myeloid DC-mediated lymphocyte protection was, at least in part, explained 
      by the capacity of the myeloid DCs to neutralize extracellular oxygen radicals, 
      which, in turn, was reversible upon coincubation with a catalase inhibitor. Our 
      results are suggestive of a novel aspect of DC-lymphocyte interaction that may 
      have implications for lymphocyte function in inflamed tissue.
FAU - Thoren, Fredrik B
AU  - Thoren FB
AD  - Department of Infectious Medicine, Sahlgrenska Academy at Goteborg University, 
      Guldhedsgatan 10b, S-413 46 Goteborg, Sweden.
FAU - Betten, Asa
AU  - Betten A
FAU - Romero, Ana I
AU  - Romero AI
FAU - Hellstrand, Kristoffer
AU  - Hellstrand K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antioxidants)
RN  - 0 (Free Radicals)
RN  - EC 1.11.1.6 (Catalase)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Antioxidants/*metabolism
MH  - Apoptosis/*immunology
MH  - Catalase/antagonists & inhibitors/metabolism
MH  - Cell Communication/immunology
MH  - Cells, Cultured
MH  - Dendritic Cells/enzymology/*metabolism
MH  - Free Radicals/metabolism
MH  - Humans
MH  - Killer Cells, Natural/cytology/immunology/*metabolism
MH  - Lymphocyte Activation/*immunology
MH  - Myeloid Cells/*metabolism
MH  - Oxidative Stress/immunology
MH  - Oxygen/*metabolism
MH  - T-Lymphocytes/cytology/immunology/*metabolism
EDAT- 2007/06/21 09:00
MHDA- 2007/08/08 09:00
CRDT- 2007/06/21 09:00
PHST- 2007/06/21 09:00 [pubmed]
PHST- 2007/08/08 09:00 [medline]
PHST- 2007/06/21 09:00 [entrez]
AID - 179/1/21 [pii]
AID - 10.4049/jimmunol.179.1.21 [doi]
PST - ppublish
SO  - J Immunol. 2007 Jul 1;179(1):21-5. doi: 10.4049/jimmunol.179.1.21.