PMID- 17580703
OWN - NLM
STAT- MEDLINE
DCOM- 20100615
LR  - 20161018
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 25
IP  - 2
DP  - 2007 Mar
TI  - [Simultaneous determination of phthalates and parabens in cosmetic products by 
      gas chromatography/mass spectrometry coupled with solid phase extraction].
PG  - 272-5
AB  - Studies have been carried out on the simultaneous determination of 8 phthalates, 
      i. e. di-ethyl phthalate (DEP) , di-propyl phthalate (DPP) , di-isobutyl 
      phthalate (DIBP) , dibutyl phthalate (DBP) , benzyl butyl phthalate ( BBP) , 
      di-cyclohexyl phthalate (DCHP) , di-(2-ethylhexyl) phthalate (DEHP), di-octyl 
      phthalate (DOP) and 4 parabens, i. e. methylparaben (MPB), ethylparaben (EPB), 
      propyl paraben (PPB), and butyl paraben (BPB) by gas chromatography in 
      combination with mass spectrometry (GC/MS) in electron ionisation mode (EI) with 
      selected-ion monitoring (SIM) acquisition method. The phthalates and parabens in 
      15 cosmetic products, including hair sprays, perfumes, deodorants, cream, lotion, 
      etc. were determined. The determination of the samples were performed after 
      sonication-assisted extraction with methanol, cleaned up with an LC-C18 column (3 
      mL) and analyzed by GC/MS method. The base peak (m/z 149) of the phthalates and 
      the base peak (m/z 121) of the parabens were selected for the screening studies. 
      The characteristic ions, m/z 121, 149, 177, 222 for DEP; m/z 149, 191, 209 for 
      DPP; m/z 57, 149, 223 for DIBP; m/z 104, 149 for DBP; m/z 91, 132, 149, 206 for 
      BBP; m/z 55, 149, 167 for DCHP; m/z 113, 149, 167, 279 for DEHP; m/z 149, 279 for 
      DOP; m/z 65, 93, 121, 152 for MPB; m/z 93, 121, 138, 166 for EPB; m/z 93, 121, 
      138, 180 for PPB; and m/z 93, 121, 138, 194 for BPB were chosen for quantitative 
      studies. These techniques are capable to detect phthalates and parabens at the 
      level of 0. 1 -5. 0 microg/kg. Overall recoveries were 80% - 100% with relative 
      standard deviations (RSDs) less than 10%. Only one of the 15 examined samples was 
      free from phthalates and parabens. The rest 14 samples were found to contain at 
      least 3 or more of these phthalates and/or parabens. The predominant phthalates 
      detected in the studied samples were MPB, PPB, DPP, DCHP and DEHP. The residue 
      levels were at 1. 42 -4 278 mg/kg.
FAU - Shen, Haoyu
AU  - Shen H
AD  - Analysis and Testing Center, Ningbo Institute of Technology, Zhejiang University, 
      Ningbo 315100, China. haoyushen2000@yahoo.com
FAU - Ying, Liyan
AU  - Ying L
FAU - Cao, Yunfeng
AU  - Cao Y
FAU - Pan, Gang
AU  - Pan G
FAU - Zhou, Lu
AU  - Zhou L
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Cosmetics)
RN  - 0 (Parabens)
RN  - 0 (Phthalic Acids)
SB  - IM
MH  - Cosmetics/*analysis
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Parabens/*analysis
MH  - Phthalic Acids/*analysis
MH  - Reproducibility of Results
MH  - Solid Phase Extraction/*methods
EDAT- 2007/06/22 09:00
MHDA- 2010/06/16 06:00
CRDT- 2007/06/22 09:00
PHST- 2007/06/22 09:00 [pubmed]
PHST- 2010/06/16 06:00 [medline]
PHST- 2007/06/22 09:00 [entrez]
PST - ppublish
SO  - Se Pu. 2007 Mar;25(2):272-5.