PMID- 17581841
OWN - NLM
STAT- MEDLINE
DCOM- 20071017
LR  - 20200930
IS  - 0363-6119 (Print)
IS  - 0363-6119 (Linking)
VI  - 293
IP  - 3
DP  - 2007 Sep
TI  - Brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus 
      reduces energy intake.
PG  - R1003-12
AB  - Recent studies show that brain-derived neurotrophic factor (BDNF) decreases 
      feeding and body weight after peripheral and ventricular administration. BDNF 
      mRNA and protein, and its receptor tyrosine kinase B (TrkB) are widely 
      distributed in the hypothalamus and other brain regions. However, there are few 
      reports on specific brain sites of actions for BDNF. We evaluated the effect of 
      BDNF in the hypothalamic paraventricular nucleus (PVN) on feeding. BDNF injected 
      unilaterally or bilaterally into the PVN of food-deprived and nondeprived rats 
      significantly decreased feeding and body weight gain within the 0- to 24-h and 
      24- to 48-h postinjection intervals. Effective doses producing inhibition of 
      feeding behavior did not establish a conditioned taste aversion. PVN BDNF 
      significantly decreased PVN neuropeptide Y (NPY)-induced feeding at 1, 2, and 4 h 
      following injection. BDNF administration in the PVN abolished 
      food-restriction-induced NPY gene expression in the hypothalamic arcuate nucleus. 
      In conclusion, BDNF in the PVN significantly decreases food intake and body 
      weight gain, suggesting that the PVN is an important site of action for BDNF in 
      its effects on energy metabolism. Furthermore, BDNF appears to interact with NPY 
      in its anorectic actions, although a direct effect on NPY remains to be 
      established.
FAU - Wang, ChuanFeng
AU  - Wang C
AD  - Veterans Affairs Medical Center, Research Service (151), One Veterans Drive, 
      Minneapolis, MN 55417, USA. cwang@umn.edu
FAU - Bomberg, Eric
AU  - Bomberg E
FAU - Billington, Charles
AU  - Billington C
FAU - Levine, Allen
AU  - Levine A
FAU - Kotz, Catherine M
AU  - Kotz CM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20070620
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
RN  - 0 (Appetite Stimulants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (DNA Primers)
RN  - 0 (Neuropeptide Y)
SB  - IM
CIN - Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R988-91. PMID: 17596322
MH  - Animals
MH  - Appetite Stimulants/pharmacology
MH  - Arcuate Nucleus of Hypothalamus/physiology
MH  - Body Weight/drug effects
MH  - Brain-Derived Neurotrophic Factor/administration & dosage/*pharmacology
MH  - Catheterization
MH  - DNA Primers
MH  - Eating/drug effects
MH  - Energy Intake/*drug effects
MH  - Food Deprivation/physiology
MH  - Gliosis/chemically induced/pathology
MH  - Male
MH  - Neuropeptide Y/pharmacology
MH  - Paraventricular Hypothalamic Nucleus/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Taste/drug effects
EDAT- 2007/06/22 09:00
MHDA- 2007/10/18 09:00
CRDT- 2007/06/22 09:00
PHST- 2007/06/22 09:00 [pubmed]
PHST- 2007/10/18 09:00 [medline]
PHST- 2007/06/22 09:00 [entrez]
AID - 00011.2007 [pii]
AID - 10.1152/ajpregu.00011.2007 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R1003-12. doi: 
      10.1152/ajpregu.00011.2007. Epub 2007 Jun 20.