PMID- 17582562
OWN - NLM
STAT- MEDLINE
DCOM- 20070814
LR  - 20071203
IS  - 1537-6591 (Electronic)
IS  - 1058-4838 (Linking)
VI  - 45 Suppl 1
DP  - 2007 Jul 15
TI  - Cell-mediated immunity and antibody responses elicited by attenuated Salmonella 
      enterica Serovar Typhi strains used as live oral vaccines in humans.
PG  - S15-9
AB  - The development of improved typhoid vaccines is a high global public health 
      priority. However, their development has been hampered by a lack of information 
      regarding the specific determinants of protective immunity to Salmonella enterica 
      serovar Typhi (S. Typhi) infection in humans. Although antibodies to S. Typhi O, 
      H, and Vi appear to be involved in protection against S. Typhi infection, it is 
      unknown whether such antibodies mediate protection, act in conjunction with other 
      adaptive responses, or serve as a surrogate for the presence of other, more 
      dominant protective immune responses (e.g., cell-mediated immunity [CMI]). CMI 
      responses elicited by immunization of subjects with attenuated S. Typhi oral 
      vaccines include lymphoproliferation; production of type 1 cytokines (e.g., 
      interferon- gamma and tumor necrosis factor- alpha ); and classical major 
      histocompatibility complex (MHC) class Ia-restricted and novel, nonclassical MHC 
      class Ib (human leukocyte antigen [HLA]-E)-restricted CD8(+) cytotoxic T cell 
      responses. In sum, human immunity to S. Typhi elicited by immunization is 
      unexpectedly broad and complex. However, the immunologic correlates of protection 
      remain largely undefined.
FAU - Sztein, Marcelo B
AU  - Sztein MB
AD  - Center for Vaccine Development and Departments of Pediatrics and Medicine, 
      University of Maryland School of Medicine, Baltimore, MD 21201, USA. 
      msztein@medicine.umaryland.edu
LA  - eng
GR  - N01-AI-30028/AI/NIAID NIH HHS/United States
GR  - R01-AI-036525/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Polysaccharides, Bacterial)
RN  - 0 (Typhoid-Paratyphoid Vaccines)
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Vi polysaccharide vaccine, typhoid)
SB  - IM
MH  - Antibody Affinity
MH  - Antigens, Bacterial/immunology
MH  - Humans
MH  - *Immunity, Cellular
MH  - Immunoglobulin G
MH  - Polysaccharides, Bacterial/*immunology
MH  - Salmonella typhi/*immunology
MH  - T-Lymphocytes, Cytotoxic/immunology
MH  - T-Lymphocytes, Helper-Inducer/immunology
MH  - Typhoid-Paratyphoid Vaccines/*immunology
MH  - Vaccines, Attenuated/immunology
RF  - 31
EDAT- 2007/07/14 09:00
MHDA- 2007/08/19 09:00
CRDT- 2007/07/14 09:00
PHST- 2007/07/14 09:00 [pubmed]
PHST- 2007/08/19 09:00 [medline]
PHST- 2007/07/14 09:00 [entrez]
AID - CID50029 [pii]
AID - 10.1086/518140 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2007 Jul 15;45 Suppl 1:S15-9. doi: 10.1086/518140.