PMID- 17583950
OWN - NLM
STAT- MEDLINE
DCOM- 20070823
LR  - 20191210
IS  - 0163-3864 (Print)
IS  - 0163-3864 (Linking)
VI  - 70
IP  - 7
DP  - 2007 Jul
TI  - Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of 
      hypoxia-inducible factor-1.
PG  - 1093-7
AB  - The hypoxia-inducible factor-1 (HIF-1) has been known to be correlated to the 
      adaptation and proliferation of tumor cells; therefore HIF-1 has become an 
      important target in the development of anticancer drugs. A phytochemical study of 
      the CHCl3-soluble fraction of Salvia miltiorrhiza, which strongly inhibited 
      hypoxia-induced reporter gene expression, led to the isolation of 12 
      abietane-type diterpenes. Of these compounds, sibiriquinone A (1), sibiriquinone 
      B (2), cryptotanshinone (3), and dihydrotanshinone I (4) potently inhibited 
      hypoxia-induced luciferase expression with IC50 values of 0.34, 3.36, 1.58, and 
      2.05 microM on AGS cells, a human gastric cancer cell line, and 0.28, 3.18, 1.36, 
      and 2.29 microM on Hep3B cells, a human hepatocarcinoma cell line, respectively. 
      Consistently, 1 and 4 dose-dependently suppressed the HIF-1alpha accumulation and 
      1 inhibited mRNA expression of vascular endothelial growth factor (VEGF) under 
      hypoxia. These results suggest that the anticancer activity of tanshinones is 
      likely at least in part associated with their inhibition of HIF-1 accumulation.
FAU - Dat, Nguyen Tien
AU  - Dat NT
AD  - Molecular Cancer Research Center, Korean Research Institute of Biosciences and 
      Biotechnology, Daejeon 305-333, Korea.
FAU - Jin, Xuejun
AU  - Jin X
FAU - Lee, Jeong-Hyung
AU  - Lee JH
FAU - Lee, Dongho
AU  - Lee D
FAU - Hong, Young-Soo
AU  - Hong YS
FAU - Lee, Kyeong
AU  - Lee K
FAU - Kim, Young Ho
AU  - Kim YH
FAU - Lee, Jung Joon
AU  - Lee JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070621
PL  - United States
TA  - J Nat Prod
JT  - Journal of natural products
JID - 7906882
RN  - 0 (Abietanes)
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 0 (Hypoxia-Inducible Factor 1)
SB  - IM
MH  - Abietanes/chemistry/*isolation & purification/*pharmacology
MH  - Antineoplastic Agents, Phytogenic/chemistry/*isolation & 
      purification/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/*antagonists & inhibitors
MH  - Korea
MH  - Plants, Medicinal/*chemistry
MH  - Salvia miltiorrhiza/*chemistry
MH  - Tumor Cells, Cultured
EDAT- 2007/06/23 09:00
MHDA- 2007/08/24 09:00
CRDT- 2007/06/23 09:00
PHST- 2007/06/23 09:00 [pubmed]
PHST- 2007/08/24 09:00 [medline]
PHST- 2007/06/23 09:00 [entrez]
AID - 10.1021/np060482d [doi]
PST - ppublish
SO  - J Nat Prod. 2007 Jul;70(7):1093-7. doi: 10.1021/np060482d. Epub 2007 Jun 21.