PMID- 17584309
OWN - NLM
STAT- MEDLINE
DCOM- 20071009
LR  - 20080528
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 18
IP  - 4
DP  - 2007 Jun
TI  - Association analysis of brain-derived neurotrophic factor gene polymorphisms in 
      asthmatic children.
PG  - 293-7
AB  - Brain-derived neurotrophic factor (BDNF) has been described to modulate airway 
      hyper-responsiveness and inflammation and was involved in late allergic reaction 
      in asthma and higher levels of circulating BDNF were present in allergic 
      asthmatics. In BDNF gene, Val66Met and C-270T polymorphisms were described. There 
      were, however, very few studies analyzing BDNF gene polymorphisms in asthma. The 
      aim of this study was to analyze the possible relationship between these two 
      polymorphisms in the BDNF gene and asthma. Fifty-six pediatric asthmatic patients 
      were analyzed, aged from 6 to 18. The diagnosis of atopic asthma was based on 
      clinical manifestation, lung function test and increased immunoglobulin E level, 
      and/or positive skin prick tests. The control group consisted of 109 healthy 
      subjects. The polymorphisms were genotyped with the use of polymerase chain 
      reaction-restriction fragment length polymorphism method. We did not observe an 
      association of Val/Met polymorphism and the presence of asthma. However, we 
      observed that Val allele is much more frequent in the male group of asthmatic 
      patients (p = 0.06). For -270C/T polymorphism, we found significant differences 
      between asthmatic patients and the control group (p = 0.041 for genotypes and p = 
      0.005 for alleles). The results may suggest a relationship between the BDNF gene 
      and asthma and male gender of asthmatic children.
FAU - Szczepankiewicz, Aleksandra
AU  - Szczepankiewicz A
AD  - Department of Pediatric Pulmonology, Allergy and Clinical Immunology, IIIrd 
      Department of Pediatrics, Poznan University of Medical Sciences, Poznan, Poland. 
      alszczep@amp.edu.pl
FAU - Breborowicz, Anna
AU  - Breborowicz A
FAU - Skibinska, Maria
AU  - Skibinska M
FAU - Wilkosc, Monika
AU  - Wilkosc M
FAU - Tomaszewska, Marta
AU  - Tomaszewska M
FAU - Hauser, Joanna
AU  - Hauser J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Asthma/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Restriction Fragment Length
MH  - Sex Factors
MH  - Skin Tests
EDAT- 2007/06/23 09:00
MHDA- 2007/10/10 09:00
CRDT- 2007/06/23 09:00
PHST- 2007/06/23 09:00 [pubmed]
PHST- 2007/10/10 09:00 [medline]
PHST- 2007/06/23 09:00 [entrez]
AID - PAI525 [pii]
AID - 10.1111/j.1399-3038.2007.00525.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2007 Jun;18(4):293-7. doi: 
      10.1111/j.1399-3038.2007.00525.x.