PMID- 17585940
OWN - NLM
STAT- MEDLINE
DCOM- 20080807
LR  - 20220317
IS  - 0022-3956 (Print)
IS  - 0022-3956 (Linking)
VI  - 42
IP  - 7
DP  - 2008 Jun
TI  - Serum brain-derived neurotrophic factor levels in patients with major depression: 
      effects of antidepressants.
PG  - 521-5
AB  - This study tried to investigate the relationships between serum brain-derived 
      neurotrophic factor (BDNF) protein levels and major depressive patients and 
      discuss the effects of antidepressants on the serum BDNF protein levels. A total 
      of 218 participants, including 111 patients with major depression (91 women) and 
      107 healthy controls (65 women), were recruited in this study. Serum BDNF protein 
      levels were measured using an ELISA kit. Psychiatric diagnoses were made 
      according to DSM-IV criteria. Severity of major depression was assessed by the 
      17-item Hamilton Depression Rating Scale. Using analysis of covariance with age 
      adjustment, there were significantly low serum BDNF protein levels in depressive 
      patients than healthy controls in women (F=7.530, p=0.007), but not in men. 
      Additionally, changes in serum BDNF protein levels were significantly increased 
      in 79 patients taking antidepressants during a period of 4 weeks (t=2.116, 
      p=0.038), especially in 61 women (t=2.542, p=0.014). Age-adjusted ANCOVA revealed 
      no significant differences in serum BDNF protein levels between 58 responders and 
      21 non-responders (F=0.008, P=0.928). In responders, there were significantly 
      increased changes in serum BDNF protein levels in 44 women (t=2.501, p=0.016), 
      but not in 14 men (t=-0.767, p=0.457). These analytical results suggest that low 
      serum BDNF may play an important role in depressive women and antidepressant 
      treatment significantly increase serum BDNF. However, further studies of larger 
      populations are necessary to confirm these results and further elucidate the 
      effects of different classes of antidepressants on serum BDNF protein levels.
FAU - Huang, Tiao-Lai
AU  - Huang TL
AD  - Department of Psychiatry, Chang Gung Memorial Hospital-Kaohsiung Medical Center, 
      Chang Gung University College of Medicine, Kaohsiung, Taiwan. 
      a540520@adm.cgmh.org.tw
FAU - Lee, Chien-Te
AU  - Lee CT
FAU - Liu, Yu-Li
AU  - Liu YL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070621
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Antidepressive Agents/*therapeutic use
MH  - Body Mass Index
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder, Major/*blood/*drug therapy/physiopathology
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Neuronal Plasticity/physiology
MH  - Prevalence
MH  - Severity of Illness Index
MH  - Sex Factors
EDAT- 2007/06/26 09:00
MHDA- 2008/08/08 09:00
CRDT- 2007/06/26 09:00
PHST- 2007/01/22 00:00 [received]
PHST- 2007/04/10 00:00 [revised]
PHST- 2007/05/10 00:00 [accepted]
PHST- 2007/06/26 09:00 [pubmed]
PHST- 2008/08/08 09:00 [medline]
PHST- 2007/06/26 09:00 [entrez]
AID - S0022-3956(07)00091-X [pii]
AID - 10.1016/j.jpsychires.2007.05.007 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2008 Jun;42(7):521-5. doi: 10.1016/j.jpsychires.2007.05.007. 
      Epub 2007 Jun 21.