PMID- 17587309
OWN - NLM
STAT- MEDLINE
DCOM- 20071107
LR  - 20161124
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 103
IP  - 1
DP  - 2007 Oct
TI  - Hyperammonaemia alters the mechanisms by which metabotropic glutamate receptors 
      in nucleus accumbens modulate motor function.
PG  - 38-46
AB  - Activation of metabotropic glutamate receptors by injecting 
      (S)3,5-dihydroxyphenylglycine (DHPG) in nucleus accumbens (NAcc) increases motor 
      activity by different mechanisms in control rats and in rats with chronic liver 
      failure due to portacaval shunt. In control rats DHPG increases extracellular 
      dopamine in NAcc and induces locomotion by activating the 'normal' circuit: 
      NAcc-->ventral pallidum-->medial-dorsal thalamus-->prefrontal cortex, which is 
      not activated in portacaval shunt rats. In these rats, DHPG activates an 
      'alternative' circuit: NAcc-->substantia nigra pars reticulata-->ventro-medial 
      thalamus-->prefrontal cortex, which is not activated in control rats. The reasons 
      by which liver failure leads to activation of this 'alternative' circuit remain 
      unclear. The aim of this work was to assess whether hyperammonaemia could be 
      responsible for the alterations found in chronic liver failure. We injected DHPG 
      in NAcc of control or hyperammonaemic rats and analysed, by in vivo brain 
      microdialysis, the neurochemical responses of the 'normal' and 'alternative' 
      circuits. In hyperammonaemic rats DHPG injection in NAcc activates both the 
      'normal' and 'alternative' circuits. In hyperammonaemia, activation of the 
      'alternative' circuit and increased motor response following metabotropic 
      glutamate receptors activation in NAcc seem due to an increase in extracellular 
      glutamate which activates AMPA receptors.
FAU - Cauli, Omar
AU  - Cauli O
AD  - Laboratory of Neurobiology, Centro de Investigacion Principe Felipe, Valencia, 
      Spain.
FAU - Mlili, Nisrin
AU  - Mlili N
FAU - Rodrigo, Regina
AU  - Rodrigo R
FAU - Felipo, Vicente
AU  - Felipo V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070622
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 0 (Quaternary Ammonium Compounds)
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - 0 (Resorcinols)
RN  - 5YR2N37E6D (3,5-dihydroxyphenylglycine)
RN  - TE7660XO1C (Glycine)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Excitatory Amino Acid Agonists/pharmacology
MH  - Glycine/*analogs & derivatives/pharmacology
MH  - Hyperammonemia/chemically induced/*metabolism
MH  - Male
MH  - Microdialysis
MH  - Motor Activity/*drug effects
MH  - Neural Pathways/drug effects/physiopathology
MH  - Nucleus Accumbens/drug effects/metabolism/*physiopathology
MH  - Prefrontal Cortex/drug effects/physiopathology
MH  - Quaternary Ammonium Compounds
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Metabotropic Glutamate/drug effects/*metabolism
MH  - Resorcinols/*pharmacology
MH  - Substantia Nigra/drug effects/physiopathology
MH  - Thalamus/drug effects/physiopathology
EDAT- 2007/06/26 09:00
MHDA- 2007/11/08 09:00
CRDT- 2007/06/26 09:00
PHST- 2007/06/26 09:00 [pubmed]
PHST- 2007/11/08 09:00 [medline]
PHST- 2007/06/26 09:00 [entrez]
AID - JNC4734 [pii]
AID - 10.1111/j.1471-4159.2007.04734.x [doi]
PST - ppublish
SO  - J Neurochem. 2007 Oct;103(1):38-46. doi: 10.1111/j.1471-4159.2007.04734.x. Epub 
      2007 Jun 22.