PMID- 17587571
OWN - NLM
STAT- MEDLINE
DCOM- 20071120
LR  - 20161124
IS  - 0960-894X (Print)
IS  - 0960-894X (Linking)
VI  - 17
IP  - 17
DP  - 2007 Sep 1
TI  - Synthesis and evaluation of a phosphonate analogue of the soluble guanylate 
      cyclase activator YC-1.
PG  - 4938-41
AB  - Soluble guanylate cyclase (sGC) is activated by the known benzylindazole 
      derivative YC-1 [1-benzyl-3-(5'-hydroxymethyl-2'-furyl)-indazole]. YC-1 also acts 
      synergistically with CO, activating sGC to a level comparable to that achieved 
      upon binding of nitric oxide, the endogenous activator of sGC. We here describe 
      the synthesis of a YC-1 phosphonate analogue with improved aqueous solubility as 
      well as its effects on sGC.
FAU - Martin, Nathaniel I
AU  - Martin NI
AD  - Department of Chemistry, University of California, Berkeley, CA 94720, USA.
FAU - Derbyshire, Emily R
AU  - Derbyshire ER
FAU - Marletta, Michael A
AU  - Marletta MA
LA  - eng
PT  - Journal Article
DEP - 20070614
PL  - England
TA  - Bioorg Med Chem Lett
JT  - Bioorganic & medicinal chemistry letters
JID - 9107377
RN  - 0 (Alcohols)
RN  - 0 (Enzyme Activators)
RN  - 0 (Indazoles)
RN  - 0 (Organophosphonates)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 154453-18-6 (3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 42VZT0U6YR (Heme)
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - EC 4.6.1.2 (Guanylate Cyclase)
RN  - EC 4.6.1.2 (Soluble Guanylyl Cyclase)
SB  - IM
MH  - Alcohols/chemistry
MH  - Chemistry, Pharmaceutical/*methods
MH  - Drug Design
MH  - Electrons
MH  - Enzyme Activation
MH  - Enzyme Activators/*chemical synthesis/chemistry
MH  - Guanosine Triphosphate/chemistry
MH  - Guanylate Cyclase/metabolism
MH  - Heme/chemistry
MH  - Indazoles/chemical synthesis/*chemistry
MH  - Kinetics
MH  - Models, Chemical
MH  - Nitric Oxide/chemistry
MH  - Organophosphonates/*chemistry
MH  - Phosphorylation
MH  - Receptors, Cytoplasmic and Nuclear/metabolism
MH  - Soluble Guanylyl Cyclase
MH  - Temperature
EDAT- 2007/06/26 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/06/26 09:00
PHST- 2007/04/26 00:00 [received]
PHST- 2007/06/06 00:00 [revised]
PHST- 2007/06/07 00:00 [accepted]
PHST- 2007/06/26 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/06/26 09:00 [entrez]
AID - S0960-894X(07)00715-9 [pii]
AID - 10.1016/j.bmcl.2007.06.039 [doi]
PST - ppublish
SO  - Bioorg Med Chem Lett. 2007 Sep 1;17(17):4938-41. doi: 10.1016/j.bmcl.2007.06.039. 
      Epub 2007 Jun 14.