PMID- 17587695
OWN - NLM
STAT- MEDLINE
DCOM- 20070926
LR  - 20131121
IS  - 0916-8451 (Print)
IS  - 0916-8451 (Linking)
VI  - 71
IP  - 6
DP  - 2007 Jun
TI  - Effects of a hop water extract on the compound 48/80-stimulated vascular 
      permeability in ICR mice and histamine release from OVA-sensitized BALB/c mice.
PG  - 1577-81
AB  - The antiallergic properties of a hop water extract (HWE) were studied by 
      evaluating the Evans blue leakage from ICR mice caused by compound 48/80 
      stimulation, and the histamine release from ovalbumin (OVA)-sensitized BALB/c 
      mice. An oral administration of HWE significantly inhibited the vascular 
      permeability and histamine release. HWE itself did not have any influence on the 
      total and antigen-specific immunoglobulin E (IgE) production in OVA-sensitized 
      mice. These results indicate that HWE exerted an antiallergic effect by 
      inhibiting the release of chemical mediators from mast cells and basophiles.
FAU - Segawa, Shuichi
AU  - Segawa S
AD  - Frontier Laboratories of Value Creation, Sapporo Breweries, Japan. 
      syuuichi.segawa@sapporobeer.co.jp
FAU - Takata, Yoshihiro
AU  - Takata Y
FAU - Kaneda, Hirotaka
AU  - Kaneda H
FAU - Watari, Junji
AU  - Watari J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Biosci Biotechnol Biochem
JT  - Bioscience, biotechnology, and biochemistry
JID - 9205717
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Plant Extracts)
RN  - 059QF0KO0R (Water)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/*pharmacology
MH  - Basophils/drug effects/immunology
MH  - Capillary Permeability/*drug effects/immunology
MH  - Humulus/*immunology
MH  - Mast Cells/drug effects/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred ICR
MH  - Ovalbumin/immunology
MH  - Plant Extracts/*pharmacology
MH  - Water
MH  - p-Methoxy-N-methylphenethylamine/pharmacology
EDAT- 2007/06/26 09:00
MHDA- 2007/09/27 09:00
CRDT- 2007/06/26 09:00
PHST- 2007/06/26 09:00 [pubmed]
PHST- 2007/09/27 09:00 [medline]
PHST- 2007/06/26 09:00 [entrez]
AID - JST.JSTAGE/bbb/70047 [pii]
AID - 10.1271/bbb.70047 [doi]
PST - ppublish
SO  - Biosci Biotechnol Biochem. 2007 Jun;71(6):1577-81. doi: 10.1271/bbb.70047.