PMID- 17588845
OWN - NLM
STAT- MEDLINE
DCOM- 20070828
LR  - 20161013
IS  - 0929-6646 (Print)
IS  - 0929-6646 (Linking)
VI  - 106
IP  - 6
DP  - 2007 Jun
TI  - Familial sarcoidosis in Taiwan.
PG  - 499-503
AB  - Sarcoidosis is a multisystemic granulomatous disease of unknown etiology and is 
      uncommon in Taiwan. No cases of familial sarcoidosis have been reported in 
      Taiwan. In this article, we report a mother and son pair who had sarcoidosis. The 
      56-year-old mother sought medical help for chronic cough for 3 months in 1993. 
      Enlarged mediastinal lymph nodes were demonstrated on chest computed tomography. 
      Besides, two small erythematous papules on her face were observed. 
      Mediastinoscopic biopsy and skin biopsy showed non-caseating granulomatous 
      inflammation. Sarcoidosis was thus diagnosed. The human leukocyte antigen 
      (HLA)-typing of the patient was HLA-A2, A11, B35, B39, CW4, CW7, DR8 and DQ6. 
      Eleven years later, her son was also diagnosed with sarcoidosis proved by 
      mediastinoscopic biopsy. His HLA-typing was HLA-A2, A24, B39, B48, CW7, CW8, DR8 
      and DQ6. This is the first report of familial sarcoidosis in Chinese people. More 
      cases are needed for further investigation of genetic predisposition among 
      Chinese people.
FAU - Perng, Reury-Perng
AU  - Perng RP
AD  - Chest Department, Taipei Veterans General Hospital, National Yang-Ming 
      University, Taipei, Taiwan.
FAU - Chou, Kun-Ta
AU  - Chou KT
FAU - Chu, Hsi
AU  - Chu H
FAU - Chung, Yu-Mei
AU  - Chung YM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Singapore
TA  - J Formos Med Assoc
JT  - Journal of the Formosan Medical Association = Taiwan yi zhi
JID - 9214933
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Lymph Nodes/pathology
MH  - Male
MH  - Middle Aged
MH  - Sarcoidosis/*genetics/pathology
MH  - Taiwan
EDAT- 2007/06/26 09:00
MHDA- 2007/08/29 09:00
CRDT- 2007/06/26 09:00
PHST- 2007/06/26 09:00 [pubmed]
PHST- 2007/08/29 09:00 [medline]
PHST- 2007/06/26 09:00 [entrez]
AID - S0929-6646(09)60301-6 [pii]
AID - 10.1016/S0929-6646(09)60301-6 [doi]
PST - ppublish
SO  - J Formos Med Assoc. 2007 Jun;106(6):499-503. doi: 10.1016/S0929-6646(09)60301-6.