PMID- 17589596
OWN - NLM
STAT- MEDLINE
DCOM- 20080306
LR  - 20181113
IS  - 0091-6765 (Print)
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Linking)
VI  - 115
IP  - 6
DP  - 2007 Jun
TI  - Dietary arsenic exposure in bangladesh.
PG  - 889-93
AB  - BACKGROUND: Millions of people in Bangladesh are at risk of chronic arsenic 
      toxicity from drinking contaminated groundwater, but little is known about diet 
      as an additional source of As exposure. METHODS: We employed a duplicate diet 
      survey to quantify daily As intake in 47 women residing in Pabna, Bangladesh. All 
      samples were analyzed for total As, and a subset of 35 samples were measured for 
      inorganic arsenic (iAs) using inductively coupled plasma mass spectrometry 
      equipped with a dynamic reaction cell. RESULTS: Median daily total As intake was 
      48 microg As/day [interquartile range (IQR), 33-67) from food and 4 microg As/day 
      (IQR, 2-152) from drinking water. On average, iAs comprised 82% of the total As 
      detected in dietary samples. After adjusting for the estimated inorganic 
      fraction, 34% [95% confidence interval (CI), 21-49%] of all participants exceeded 
      the World Health Organization's provisional tolerable daily intake (PTDI) of 2.1 
      microg As/kg-day. Two of the 33 women who used a well with < 50 microg As/L 
      exceeded this recommendation. CONCLUSIONS: When drinking water concentrations 
      exceeded the Bangladesh drinking water standard of 50 microg As/L, ingested water 
      was the dominant source of exposure. However, as drinking water As concentrations 
      decrease, the relative contribution of dietary As sources becomes more important 
      to ingested dose. The combined intake from both diet and drinking water can cause 
      some individuals to exceed the PTDI in spite of using a tube well that contains < 
      50 microg As/L.
FAU - Kile, Molly L
AU  - Kile ML
AD  - Harvard School of Public Health, Boston, Massachusetts 02115, USA. 
      mkile@hsph.harvard.edu
FAU - Houseman, E Andres
AU  - Houseman EA
FAU - Breton, Carrie V
AU  - Breton CV
FAU - Smith, Thomas
AU  - Smith T
FAU - Quamruzzaman, Quazi
AU  - Quamruzzaman Q
FAU - Rahman, Mahmuder
AU  - Rahman M
FAU - Mahiuddin, Golam
AU  - Mahiuddin G
FAU - Christiani, David C
AU  - Christiani DC
LA  - eng
GR  - P30 ES000002/ES/NIEHS NIH HHS/United States
GR  - ES 05947/ES/NIEHS NIH HHS/United States
GR  - P42 ES005947/ES/NIEHS NIH HHS/United States
GR  - ES 011622/ES/NIEHS NIH HHS/United States
GR  - ES 00002/ES/NIEHS NIH HHS/United States
GR  - R01 ES011622/ES/NIEHS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070220
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - Adult
MH  - Arsenic/*analysis
MH  - Bangladesh
MH  - Female
MH  - Food Contamination/*analysis
MH  - Humans
MH  - Mass Spectrometry
MH  - Middle Aged
MH  - Water Supply/analysis
PMC - PMC1892146
EDAT- 2007/06/26 09:00
MHDA- 2008/03/07 09:00
PMCR- 2007/06/01
CRDT- 2007/06/26 09:00
PHST- 2006/06/27 00:00 [received]
PHST- 2007/02/20 00:00 [accepted]
PHST- 2007/06/26 09:00 [pubmed]
PHST- 2008/03/07 09:00 [medline]
PHST- 2007/06/26 09:00 [entrez]
PHST- 2007/06/01 00:00 [pmc-release]
AID - ehp0115-000889 [pii]
AID - 10.1289/ehp.9462 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2007 Jun;115(6):889-93. doi: 10.1289/ehp.9462. Epub 2007 
      Feb 20.