PMID- 17590104
OWN - NLM
STAT- MEDLINE
DCOM- 20070830
LR  - 20070625
IS  - 1130-0108 (Print)
IS  - 1130-0108 (Linking)
VI  - 99
IP  - 4
DP  - 2007 Apr
TI  - [Diagnosis and treatment of pancreatic insulinoma].
PG  - 218-22
AB  - INTRODUCTION: insulinoma is the most frequent pancreatic endocrine tumor. Its 
      preoperative diagnosis has been controversial for many years. The aim of this 
      study was to evaluate the experience in the management and treatment of this kind 
      of tumor at Hospital Ramon y Cajal. MATERIAL AND METHODS: between January 1999 
      and July 2006, 12 patients were operated on in our hospital (9 females and 3 
      males) who had been diagnosed with insulinoma, with a mean age of 56 years (16-72 
      years). RESULTS: octreotide scintigraphy allowed a diagnosis in 33.3% of cases, 
      abdominal CT in 83.3%, and echoendoscopy in 100%. Intraoperative ultrasonography 
      confirmed the presence of an insulinoma in 100% of cases. In all cases a complete 
      excision was possible, with 9 enucleations and 3 distal pancreatectomies. Two 
      patients developed a pancreatic fistula, and one a pancreatic pseudocyst that 
      healed spontaneously without surgery. The overall cure rate was 100%. After a 
      mean follow-up of 48 months no recurrences have been reported. CONCLUSION: in our 
      experience, we consider advisable that abdominal CT and echoendoscopy be 
      performed before surgery. However, the initial procedure of choice would be 
      pancreas palpation and intraoperative ultrasonography. Surgery cured 100% of 
      cases, and the procedure selected depends on size, location, distance from the 
      main pancreatic duct, and relation to multiple endocrine neoplasm 1 (MEN-1).
FAU - Priego, P
AU  - Priego P
AD  - Departamento de Cirugia General y Digestivo, Hospital Ramon y Cajal, Madrid, 
      Spain. papriego@hotmail.com
FAU - Sanjuanbenito, A
AU  - Sanjuanbenito A
FAU - Martinez Molina, E
AU  - Martinez Molina E
FAU - Lobo, E
AU  - Lobo E
FAU - Garcia Teruel, D
AU  - Garcia Teruel D
FAU - Morales, V
AU  - Morales V
FAU - Rodriguez, G
AU  - Rodriguez G
FAU - Fresneda, V
AU  - Fresneda V
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Manejo diagnostico y terapeutico del insulinoma pancreatico.
PL  - Spain
TA  - Rev Esp Enferm Dig
JT  - Revista espanola de enfermedades digestivas
JID - 9007566
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Insulinoma/*diagnosis/*surgery
MH  - Male
MH  - Middle Aged
MH  - Pancreatic Neoplasms/*diagnosis/*surgery
EDAT- 2007/06/26 09:00
MHDA- 2007/08/31 09:00
CRDT- 2007/06/26 09:00
PHST- 2007/06/26 09:00 [pubmed]
PHST- 2007/08/31 09:00 [medline]
PHST- 2007/06/26 09:00 [entrez]
PST - ppublish
SO  - Rev Esp Enferm Dig. 2007 Apr;99(4):218-22.