PMID- 17590450
OWN - NLM
STAT- MEDLINE
DCOM- 20071012
LR  - 20191210
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 182
IP  - 1
DP  - 2007 Aug 22
TI  - The effects of energy-rich diets on discrimination reversal learning and on BDNF 
      in the hippocampus and prefrontal cortex of the rat.
PG  - 57-66
AB  - Male rats received normal chow or high-fat diets rich in dextrose (HFD) or 
      sucrose (HFS). Half of the rats received 90-day unrestricted access to their diet 
      prior to training, whereas the other half were food restricted throughout the 
      study. We evaluated the effects of these dietary manipulations on discrimination 
      and reversal performance and on post-training levels of brain-derived 
      neurotrophic factor (BDNF) in the prefrontal cortex and the ventral and dorsal 
      hippocampus. Neither diet nor restriction condition affected discrimination 
      acquisition. However, prior unrestricted access to the HFD diet impaired 
      discrimination reversal learning and reduced BDNF in the prefrontal cortex and 
      ventral hippocampus. Also, rats given the HFD diet responded more than controls 
      to the previously rewarded cue at the outset of discrimination reversal. The 
      results suggest that consumption of the HFD diet may have had enduring effects on 
      learning processes, some of which may contribute to the control of intake 
      regulation.
FAU - Kanoski, Scott E
AU  - Kanoski SE
AD  - The Ingestive Behavior Research Center, Purdue University, IN, USA. 
      skanoski@purdue.edu
FAU - Meisel, Robert L
AU  - Meisel RL
FAU - Mullins, Amanda J
AU  - Mullins AJ
FAU - Davidson, Terry L
AU  - Davidson TL
LA  - eng
GR  - R01 DA13680/DA/NIDA NIH HHS/United States
GR  - R01 HD028792/HD/NICHD NIH HHS/United States
GR  - R01 HD028792-13/HD/NICHD NIH HHS/United States
GR  - R01 DA013680/DA/NIDA NIH HHS/United States
GR  - R01 HD29792/HD/NICHD NIH HHS/United States
GR  - R01 HD028792-14/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070522
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dietary Fats)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Avoidance Learning/*physiology
MH  - Behavior, Animal
MH  - Body Weight
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Dietary Fats/*administration & dosage
MH  - Discrimination, Psychological/*physiology
MH  - Hippocampus/*physiology
MH  - Male
MH  - Prefrontal Cortex/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC2042136
MID - NIHMS27668
EDAT- 2007/06/26 09:00
MHDA- 2007/10/13 09:00
PMCR- 2008/08/22
CRDT- 2007/06/26 09:00
PHST- 2007/02/08 00:00 [received]
PHST- 2007/04/26 00:00 [revised]
PHST- 2007/05/07 00:00 [accepted]
PHST- 2007/06/26 09:00 [pubmed]
PHST- 2007/10/13 09:00 [medline]
PHST- 2007/06/26 09:00 [entrez]
PHST- 2008/08/22 00:00 [pmc-release]
AID - S0166-4328(07)00251-3 [pii]
AID - 10.1016/j.bbr.2007.05.004 [doi]
PST - ppublish
SO  - Behav Brain Res. 2007 Aug 22;182(1):57-66. doi: 10.1016/j.bbr.2007.05.004. Epub 
      2007 May 22.