PMID- 17590513
OWN - NLM
STAT- MEDLINE
DCOM- 20071029
LR  - 20220310
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 422
IP  - 2
DP  - 2007 Jul 11
TI  - BDNF plasma levels in acute stroke.
PG  - 128-30
AB  - The transport of brain derived neurotrophic factor (BDNF) across the blood-brain 
      barrier (BBB) is negligible in normal conditions. However, BDNF might pass 
      through the BBB when BBB is disrupted by a pathological condition such as stroke. 
      This migration of BDNF through the BBB might be important during post-ischemic 
      phase since BDNF can exert a protective action in the site of lesion. This study 
      aimed to investigate plasma levels of BDNF in the acute phase of stroke in 
      humans. Serial venous blood samples were taken in ten patients with acute stroke 
      at the admission to the Stroke Unit and on the following 4 days. In the same 
      samples we also evaluated the plasma levels of S100beta protein, a marker of BBB 
      disruption. There was no significant change in BDNF plasma levels in our 
      patients, even in the presence of a pronounced BBB dysfunction, as demonstrated 
      by a significant increase of S100beta protein concentrations at days 2 and 3 
      after stroke. Our data, though indirectly, suggest that there is no significant 
      increase in endogenous extracellular BDNF after a stroke in humans.
FAU - Di Lazzaro, V
AU  - Di Lazzaro V
AD  - Institute of Neurology, Universita Cattolica, L.go A. Gemelli 8, 00168 Rome, 
      Italy. vdilazzaro@rm.unicatt.it
FAU - Profice, P
AU  - Profice P
FAU - Pilato, F
AU  - Pilato F
FAU - Dileone, M
AU  - Dileone M
FAU - Florio, L
AU  - Florio L
FAU - Tonali, P A
AU  - Tonali PA
FAU - Angelucci, F
AU  - Angelucci F
LA  - eng
PT  - Journal Article
DEP - 20070608
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (S100 Calcium Binding Protein beta Subunit)
RN  - 0 (S100 Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/analysis/blood
MH  - Blood-Brain Barrier/*metabolism/*physiopathology
MH  - Brain/blood supply/metabolism/physiopathology
MH  - Brain Infarction/blood/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Extracellular Fluid/chemistry/metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Growth Factors/blood
MH  - S100 Calcium Binding Protein beta Subunit
MH  - S100 Proteins/blood
MH  - Stroke/*blood/diagnosis/*physiopathology
MH  - Time Factors
MH  - Up-Regulation
EDAT- 2007/06/26 09:00
MHDA- 2007/10/30 09:00
CRDT- 2007/06/26 09:00
PHST- 2007/04/28 00:00 [received]
PHST- 2007/05/30 00:00 [revised]
PHST- 2007/06/05 00:00 [accepted]
PHST- 2007/06/26 09:00 [pubmed]
PHST- 2007/10/30 09:00 [medline]
PHST- 2007/06/26 09:00 [entrez]
AID - S0304-3940(07)00662-3 [pii]
AID - 10.1016/j.neulet.2007.06.001 [doi]
PST - ppublish
SO  - Neurosci Lett. 2007 Jul 11;422(2):128-30. doi: 10.1016/j.neulet.2007.06.001. Epub 
      2007 Jun 8.