PMID- 17591667
OWN - NLM
STAT- MEDLINE
DCOM- 20080118
LR  - 20161124
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Linking)
VI  - 92
IP  - 1
DP  - 2008 Jan
TI  - Aqueous humor levels of asymmetric dimethylarginine (ADMA) are positively 
      associated with monocyte chemoattractant protein-1 (MCP-1) in patients with 
      uveitis.
PG  - 93-4
AB  - BACKGROUND/AIMS: The aim of the study was to evaluate whether aqueous humor 
      levels of asymmetric dimethylarginine (ADMA) are associated with monocyte 
      chemoattractant protein-1 (MCP-1). METHODS: Aqueous humor levels of ADMA and 
      MCP-1 were measured by high-performance liquid chromatography (HPLC) and ELISA, 
      respectively, in 31 uveitis samples and nine cataract control samples. RESULTS: 
      Aqueous humor ADMA and MCP-1 levels were significantly higher in infectious or 
      non-infectious uveitis patients than in controls (0.67+/-0.04 nmol/ml vs 
      0.55+/-0.03 nmol/ml vs 0.43+/-0. 04 nmol/ml (p<0.01) and 29.0+/-11.3 ng/ml vs 
      4.5+/-1.2 ng/ml vs 0.47+/-0.1 ng/ml (p<0.01), respectively). A positive 
      correlation between ADMA and MCP-1 levels in aqueous humor was found in control 
      and uveitis patients (r = 0.33, p<0.05). CONCLUSION: The results demonstrated 
      that aqueous humor levels of ADMA were positively associated with MCP-1 in 
      humans. Our present observations suggest that aqueous humor levels of ADMA may be 
      a novel biomarker of inflammation in uveitis.
FAU - Yoshida, Y
AU  - Yoshida Y
AD  - Department of Ophthalmology, Kurume University School of Medicine, Kurume 
      830-0011, Japan.
FAU - Yamagishi, S
AU  - Yamagishi S
FAU - Ueda, S
AU  - Ueda S
FAU - Yoshimura, K
AU  - Yoshimura K
FAU - Okuda, S
AU  - Okuda S
FAU - Yamakawa, R
AU  - Yamakawa R
LA  - eng
PT  - Journal Article
DEP - 20070625
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 63CV1GEK3Y (N,N-dimethylarginine)
RN  - 94ZLA3W45F (Arginine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aqueous Humor/*chemistry
MH  - Arginine/*analogs & derivatives/analysis
MH  - Biomarkers/analysis
MH  - Chemokine CCL2/*analysis
MH  - Eye Infections/metabolism
MH  - Humans
MH  - Middle Aged
MH  - Uveitis/*metabolism/microbiology
EDAT- 2007/06/27 09:00
MHDA- 2008/01/19 09:00
CRDT- 2007/06/27 09:00
PHST- 2007/06/27 09:00 [pubmed]
PHST- 2008/01/19 09:00 [medline]
PHST- 2007/06/27 09:00 [entrez]
AID - bjo.2007.124966 [pii]
AID - 10.1136/bjo.2007.124966 [doi]
PST - ppublish
SO  - Br J Ophthalmol. 2008 Jan;92(1):93-4. doi: 10.1136/bjo.2007.124966. Epub 2007 Jun 
      25.