PMID- 17594333
OWN - NLM
STAT- MEDLINE
DCOM- 20070815
LR  - 20151113
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Linking)
VI  - 14
IP  - 7
DP  - 2007 Jul
TI  - Time course of cerebral hemodynamics in cryptococcal meningitis in HIV-negative 
      adults.
PG  - 770-6
AB  - To evaluate the cerebral hemodynamics in cryptococcal meningitis (CM) patients 
      using non-invasive studies. Serial trans-cranial color-coded sonography (TCCS) 
      and magnetic resonance angiography (MRA) studies were performed to measure the 
      cerebral vasculopathy of 12 HIV-negative CM patients. With TCCS, 8 of the 22 
      middle cerebral arteries (MCAs) showed stenotic velocities, whereas the time-mean 
      velocity (V(mean)) of the 20 anterior cerebral arteries (ACAs), 22 posterior 
      cerebral arteries (PCAs), and 12 basilar arteries (BAs) did not. In total, five 
      patients had stenotic velocities, three of whom had bilateral M1 stenosis (<50%), 
      whilst two had unilateral M1 stenosis (<50%). The V(mean) of MCA increased from 
      day 1 to day 35 and substantially decreased thereafter. The mean Pulsatility 
      Index (PI) in the studied vessels was higher during the study period. A mismatch 
      of the findings between TCCS and MRA studies were also demonstrated. There was a 
      high incidence and a longer time-period of disturbed cerebral hemodynamics during 
      the clinical course of CM. However, because of the limited case numbers for this 
      study, further large-scale studies are needed to delineate the clinical 
      characteristics and therapeutic influence of cerebrovascular insults in 
      HIV-negative CM patients.
FAU - Chang, W-N
AU  - Chang WN
AD  - Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center 
      and Chang Gung University College of Medicine, Kaohsiung, Taiwan. 
      cwenneng@ms19.hinet.net
FAU - Lu, C-H
AU  - Lu CH
FAU - Chang, H-W
AU  - Chang HW
FAU - Lui, C-C
AU  - Lui CC
FAU - Tsai, N-W
AU  - Tsai NW
FAU - Huang, C-R
AU  - Huang CR
FAU - Wang, H-C
AU  - Wang HC
FAU - Chuang, Y-C
AU  - Chuang YC
FAU - Chen, S-F
AU  - Chen SF
FAU - Chang, C-C
AU  - Chang CC
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Blood Flow Velocity
MH  - Cerebral Angiography
MH  - Cerebral Infarction/epidemiology/*etiology/physiopathology
MH  - *Cerebrovascular Circulation
MH  - Constriction, Pathologic
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Infarction, Middle Cerebral Artery/epidemiology/etiology/physiopathology
MH  - Infarction, Posterior Cerebral Artery/epidemiology/etiology/physiopathology
MH  - Magnetic Resonance Angiography
MH  - Male
MH  - Meningitis, Cryptococcal/complications/mortality/*physiopathology
MH  - Middle Aged
MH  - Middle Cerebral Artery/physiopathology
MH  - Posterior Cerebral Artery/physiopathology
MH  - Prospective Studies
MH  - Taiwan/epidemiology
MH  - Treatment Outcome
MH  - Ultrasonography, Doppler, Transcranial
EDAT- 2007/06/28 09:00
MHDA- 2007/08/19 09:00
CRDT- 2007/06/28 09:00
PHST- 2007/06/28 09:00 [pubmed]
PHST- 2007/08/19 09:00 [medline]
PHST- 2007/06/28 09:00 [entrez]
AID - ENE1852 [pii]
AID - 10.1111/j.1468-1331.2007.01852.x [doi]
PST - ppublish
SO  - Eur J Neurol. 2007 Jul;14(7):770-6. doi: 10.1111/j.1468-1331.2007.01852.x.