PMID- 17596666
OWN - NLM
STAT- MEDLINE
DCOM- 20070809
LR  - 20181113
IS  - 1011-8934 (Print)
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Linking)
VI  - 22
IP  - 3
DP  - 2007 Jun
TI  - RANTES, MCP-1, CCR2, CCR5, CXCR1 and CXCR4 gene polymorphisms are not associated 
      with the outcome of hepatitis B virus infection: results from a large scale 
      single ethnic population.
PG  - 529-35
AB  - Recovery from hepatitis B virus (HBV) infection depends on the cellular immune 
      responses. Chemokines and their receptors play significant roles in immune 
      defense. This study was undertaken to investigate the association between HBV 
      infection and single nucleotide polymorphisms (SNPs) of genes for the chemokines 
      and their receptors. Between March 2002 and February 2004, a total of 957 single 
      ethnic Korean patients were enrolled into two different groups; "HBV clearance 
      group" (n=350), who have recovered from HBV infection, and "HBV persistence 
      group" (n=607), who were repeatedly HBsAg-positive. The HBV persistence group was 
      subdivided into "inactive carrier" and "HBV progression group (chronic hepatitis 
      and cirrhosis)". We assessed polymorphisms in regulated and normal T-cell 
      expressed and secreted (RANTES) at position -403, monocyte chemoattractant 
      protein-1 (MCP-1) at position -2518, CCR2 V64I, CCR5 -2459, CXCR1 S276T and CXCR4 
      I138I using single primer extension assay. Genotype distributions of the "HBV 
      clearance versus persistence group" and "inactive carrier versus HBV progression 
      group" were compared. On the basis of unconditional logistic regression analysis 
      with adjustment for age and sex, no statistically significant association with 
      susceptibility to persistent HBV infection was observed with RANTES -403, MCP-1 
      -2518, CCR2 V64I, CCR5 -2459, CXCR1 S276T, and CXCR4 I138I polymorphisms. In 
      addition, no association of analyzed SNPs with HBV disease progression was found.
FAU - Cheong, Jae Youn
AU  - Cheong JY
AD  - Department of Gastroenterology, Genomic Research Center for Gastroenterology, 
      Ajou University School of Medicine, San-5 Wonchon-dong, Youngtong-gu, Suwon, 
      Korea.
FAU - Cho, Sung Won
AU  - Cho SW
FAU - Choi, Jeong Young
AU  - Choi JY
FAU - Lee, Jung A
AU  - Lee JA
FAU - Kim, Min Ho
AU  - Kim MH
FAU - Lee, Jong Eun
AU  - Lee JE
FAU - Hahm, Ki Baik
AU  - Hahm KB
FAU - Kim, Jin Hong
AU  - Kim JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCR2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, CCR5)
RN  - 0 (Receptors, CXCR4)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (Receptors, Interleukin-8A)
SB  - IM
MH  - Chemokine CCL2/*genetics
MH  - Chemokine CCL5/*genetics
MH  - Disease Progression
MH  - Genotype
MH  - Hepatitis B/ethnology/*genetics/*therapy
MH  - Hepatitis B virus/metabolism
MH  - Humans
MH  - Korea
MH  - *Polymorphism, Genetic
MH  - Receptors, CCR2
MH  - Receptors, CCR5/*genetics
MH  - Receptors, CXCR4/*genetics
MH  - Receptors, Chemokine/*genetics
MH  - Receptors, Interleukin-8A/*genetics
MH  - Regression Analysis
MH  - Treatment Outcome
PMC - PMC2693650
EDAT- 2007/06/29 09:00
MHDA- 2007/08/10 09:00
PMCR- 2007/06/01
CRDT- 2007/06/29 09:00
PHST- 2007/06/29 09:00 [pubmed]
PHST- 2007/08/10 09:00 [medline]
PHST- 2007/06/29 09:00 [entrez]
PHST- 2007/06/01 00:00 [pmc-release]
AID - 200706529 [pii]
AID - 10.3346/jkms.2007.22.3.529 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2007 Jun;22(3):529-35. doi: 10.3346/jkms.2007.22.3.529.