PMID- 17596718
OWN - NLM
STAT- MEDLINE
DCOM- 20071012
LR  - 20070628
IS  - 1660-2854 (Print)
IS  - 1660-2854 (Linking)
VI  - 4
IP  - 2-3
DP  - 2007
TI  - Frontotemporal dementia with tau pathology.
PG  - 236-53
AB  - Tau is a microtubule-associated protein involved in microtubule assembly and 
      stabilization. Filamentous deposits made of tau constitute a major defining 
      characteristic of several neurodegenerative diseases known as tauopathies 
      including Alzheimer's disease. The involvement of tau in neurodegeneration has 
      been clarified by the identification of genetic mutations in the tau gene in 
      cases with familial frontotemporal dementia and parkinsonism linked to chromosome 
      17 (FTDP-17). Although the mechanism through which tau mutations lead to neuronal 
      death is still unresolved, it is clear that tau mutations lead to formation of 
      tau filaments that have a different morphology, contain different types of tau 
      isoforms and produce distinct tau deposits. The range of tau pathology identified 
      in FTDP-17 recapitulates the tau pathology present in sporadic tauopathies and 
      indicates that tau dysfunction plays a major role also in these diseases.
CI  - 2007 S. Karger AG, Basel
FAU - Gasparini, Laura
AU  - Gasparini L
AD  - Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, 
      University of Cambridge, Cambridge, UK.
FAU - Terni, Beatrice
AU  - Terni B
FAU - Spillantini, Maria Grazia
AU  - Spillantini MG
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Neurodegener Dis
JT  - Neuro-degenerative diseases
JID - 101189034
RN  - 0 (tau Proteins)
SB  - IM
MH  - Animals
MH  - Dementia/genetics/*metabolism/*pathology
MH  - Humans
MH  - Tauopathies/genetics/*metabolism
MH  - tau Proteins/genetics/*metabolism
RF  - 187
EDAT- 2007/06/29 09:00
MHDA- 2007/10/13 09:00
CRDT- 2007/06/29 09:00
PHST- 2007/06/29 09:00 [pubmed]
PHST- 2007/10/13 09:00 [medline]
PHST- 2007/06/29 09:00 [entrez]
AID - 000101848 [pii]
AID - 10.1159/000101848 [doi]
PST - ppublish
SO  - Neurodegener Dis. 2007;4(2-3):236-53. doi: 10.1159/000101848.