PMID- 17596912
OWN - NLM
STAT- MEDLINE
DCOM- 20071018
LR  - 20161124
IS  - 1097-6795 (Electronic)
IS  - 0894-7317 (Linking)
VI  - 20
IP  - 10
DP  - 2007 Oct
TI  - Detection of left ventricular systolic dysfunction in cardiac amyloidosis with 
      strain rate echocardiography.
PG  - 1194-202
AB  - BACKGROUND: We examined the potential role of Doppler myocardial imaging 
      including tissue velocity imaging, strain imaging, and strain rate imaging for 
      detection of left ventricular systolic dysfunction in cardiac amyloidosis (CA) 
      and determined the minimum dataset required to make the diagnosis. METHODS AND 
      RESULTS: Doppler myocardial imaging was performed in 103 patients with 
      amyloidosis (AL). Peak longitudinal systolic tissue velocity, systolic strain 
      rate (sSR), and systolic strain (sS) were determined for 16 left ventricular 
      segments. Radial and circumferential sSR and sS were also measured. Patients with 
      increased left ventricular wall thickness were classified with advanced-CA, and 
      the remainder of the patients were classified with AL-normal-wall-thickness. The 
      global means of peak systolic tissue velocity (3.6 +/- 1.0 vs. 3.9 +/- 0.9, P = 
      .007), sSR (-0.8 +/- 0.3 vs. -1.0 +/- 0.2, P < .001), and sS (-9.9 +/- 3.7 vs. 
      -15.6 +/- 3.3, P < .001) were significantly lower in advanced-CA compared with 
      AL-normal-wall-thickness. The mean of either sSR or sS from 6 middle or all 16 
      segments similarly differentiated patients with advanced-CA from 
      AL-normal-wall-thickness. CONCLUSIONS: Longitudinal sS most accurately detects 
      longitudinal systolic dysfunction in AL and best differentiates patients with 
      advanced-CA with increased ventricular thickness from patients with 
      AL-normal-wall-thickness. Interrogation of six middle segments was sufficient in 
      identifying patients with advanced-CA. Further studies are warranted to define 
      the incremental prognostic value of these new parameters in predicting outcomes 
      for patients with AL.
FAU - Bellavia, Diego
AU  - Bellavia D
AD  - Cardiovascular Division, Mayo Clinic and Foundation, Rochester, Minneosota 55905, 
      USA.
FAU - Abraham, Theodore P
AU  - Abraham TP
FAU - Pellikka, Patricia A
AU  - Pellikka PA
FAU - Al-Zahrani, Ghormallah B
AU  - Al-Zahrani GB
FAU - Dispenzieri, Angela
AU  - Dispenzieri A
FAU - Oh, Jae K
AU  - Oh JK
FAU - Bailey, Kent R
AU  - Bailey KR
FAU - Wood, Christina M
AU  - Wood CM
FAU - Novo, Salvatore
AU  - Novo S
FAU - Miyazaki, Chinami
AU  - Miyazaki C
FAU - Miller, Fletcher A Jr
AU  - Miller FA Jr
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070626
PL  - United States
TA  - J Am Soc Echocardiogr
JT  - Journal of the American Society of Echocardiography : official publication of the 
      American Society of Echocardiography
JID - 8801388
SB  - IM
MH  - Aged
MH  - Amyloidosis/*complications/diagnosis/physiopathology
MH  - Biopsy
MH  - Blood Flow Velocity/physiology
MH  - Diagnosis, Differential
MH  - Echocardiography, Doppler, Pulsed/*methods
MH  - Follow-Up Studies
MH  - Heart Ventricles/*diagnostic imaging/pathology/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction/*physiology
MH  - Observer Variation
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Systole
MH  - Ventricular Dysfunction, Left/*diagnostic imaging/etiology/physiopathology
EDAT- 2007/06/29 09:00
MHDA- 2007/10/19 09:00
CRDT- 2007/06/29 09:00
PHST- 2006/12/05 00:00 [received]
PHST- 2007/06/29 09:00 [pubmed]
PHST- 2007/10/19 09:00 [medline]
PHST- 2007/06/29 09:00 [entrez]
AID - S0894-7317(07)00171-X [pii]
AID - 10.1016/j.echo.2007.02.025 [doi]
PST - ppublish
SO  - J Am Soc Echocardiogr. 2007 Oct;20(10):1194-202. doi: 10.1016/j.echo.2007.02.025. 
      Epub 2007 Jun 26.